MRI: Acquisition of a High Resolution Low Voltage Electron Microscope for Multidisciplinary Needs at The University of Georgia

MRI：佐治亚大学采购高分辨率低压电子显微镜以满足多学科需求

基本信息

批准号：
1919942
负责人：
Tina Salguero
金额：
$ 99.75万
依托单位：
University of Georgia Research Foundation Inc
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-01 至 2022-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1919942&HistoricalAwards=false
关键词：
MRI Acquisition Resolution Low Voltage

项目摘要

This Major Research Instrumentation (MRI) award supports the acquisition of a high-resolution low-voltage electron microscope at the University of Georgia (UGA) that enables the research, training, teaching, and outreach efforts of investigators across the physical sciences, geological and environmental sciences, biological sciences, engineering disciplines, and allied fields. The unique technical capabilities of this microscope allow the imaging and chemical analysis of samples under conditions that mitigate electron beam damage. These capabilities lead to the study of diverse materials including nanostructures, polymers, fibers, and biological specimens, which encompass research being done by 29 major users across numerous colleges, centers, departments, and laboratories at UGA. This instrument is integrated within the Georgia Electron Microscopy (GEM) core facility at UGA to permit inter- and transdisciplinary usage and collaboration. Beyond research applications and the associated training of student users, the new microscope enables the inclusion of state-of-the-art electron microscopy content in course offerings and outreach efforts. These activities are accomplished in part using GEM's Electron Theater, with an emphasis on nanoscience in the environment. In addition, the instrument is used to acquire data sets suitable for integration into K-12 STEM lesson plans.This MRI award supports the acquisition of an electron microscope capable of low-voltage operation (defined as less than or equal to 30 kV). The technical highlights of this instrument include ultra high-resolution scanning electron microscopy (UHR-SEM) imaging at low voltages; high resolution scanning transmission electron microscopy (STEM) mode, including high-angle annular dark field (HAADF) imaging and additional detectors, all operating at a low beam voltage; and analytical tools that provide quantitative composition and structure data, including electron diffraction, elemental mapping by energy dispersive X-ray spectroscopy (EDS), and electron energy-loss spectroscopy (EELS), all at low voltages. Research projects enabled by this instrument span four thematic areas: (1) inorganic nanomaterials, especially 2D nanosheets and functional materials for energy storage, electronics applications, biomedical imaging, and drug delivery applications, (2) nanogeoscience and environmental soil science, (3) new frontiers in developing high-resolution low-voltage methods for imaging biological specimens, and (4) high-resolution low-voltage imaging of nanostructured hybrid systems and soft materials, including beam-sensitive samples like polymers and fibers. In particular, the application of electron microscopy to beam-sensitive materials will provide new detailed information about sample composition, heterogeneity, structure, phase purity, and properties at the nanoscale. Additionally, the superior contrast in STEM brightfield and HAADF imaging modes, compared with TEM imaging, will allow investigators to resolve detailed organic components, such as the ligand coronas of inorganic nanostructures and interfaces between biological structures.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项主要的研究工具（MRI）奖支持佐治亚大学（UGA）的高分辨率低压电子显微镜的获得，该奖项能够在物理科学，地质和环境科学，生物科学，工程学，工程学，工程学和所有领域的研究，培训，教学和外展工作。该显微镜的独特技术能力允许在减轻电子束损伤的条件下对样品进行成像和化学分析。这些功能导致研究了各种材料，包括纳米结构，聚合物，纤维和生物标本，这些标本涵盖了由UGA众多大学，中心，部门和实验室的29个主要用户进行的研究。该仪器集成在UGA的乔治亚电子显微镜（GEM）核心设施中，以允许跨学科的使用和协作。除了研究应用程序以及对学生用户的相关培训之外，新显微镜还可以将最先进的电子显微镜内容纳入课程和外展工作。这些活动是在某种程度上使用GEM的电子剧院来完成的，重点是环境中的纳米科学。此外，该仪器用于获取适合集成到K-12 STEM课程计划的数据集。该MRI奖支持可获得能够低压操作的电子显微镜（定义为小于或等于30 kV）。该仪器的技术亮点包括低压下的超高分辨率扫描电子显微镜（UHR-SEM）成像；高分辨率扫描透射电子显微镜（STEM）模式，包括高角度环形黑场（HAADF）成像和其他检测器，所有检测器均在低光束电压下运行；提供定量组成和结构数据的分析工具，包括电子衍射，元素分散X射线光谱（EDS）和电子能量损失光谱（EEL）的元素映射，都是低压的。该乐器启用的研究项目跨越了四个主题领域：（1）无机纳米材料，尤其是2D纳米材料和用于存储能源的功能材料，电子设备应用，生物医学成像和药物输送应用，（2）纳米方面和环境土壤科学，（3）在高分辨率的低探测器中，且生物学高量的新领域，以及（3）生物学高量和（4），且生物学高量 - 繁殖图像4（4），（4）纳米结构杂种系统和软材料的成像，包括对聚合物和纤维等光束敏感的样品。特别是，将电子显微镜应用于光束敏感的材料将提供有关纳米级样品组成，异质性，结构，相位纯度和性质的新详细信息。此外，与TEM成像相比，STEM BRIGHTFIELD和HAADF成像模式的优势对比度将使研究人员能够解决详细的有机成分，例如无机纳米结构的配体冠状动脉以及生物结构之间的界面。该奖项奖在NSF的法定任务中反映了通过评估的构成群体的范围，并反映了构成构成的依据和构成的构成师的构成师，并构成了基础。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Localized alteration of ferrihydrite natural organic matter coprecipitates following reaction with Fe(II)

水铁矿天然有机物与 Fe(II) 反应后共沉淀的局部变化

DOI：
10.1002/saj2.20366
发表时间：
2022
期刊：
Soil Science Society of America Journal
影响因子：
2.9
作者：
Noor, Nadia;Thompson, Aaron
通讯作者：
Thompson, Aaron

Combining Doxorubicin-Conjugated Polymeric Nanoparticles and 5-Aminolevulinic Acid for Enhancing Radiotherapy against Lung Cancer

结合阿霉素缀合的聚合物纳米颗粒和 5-氨基乙酰丙酸以增强肺癌放射治疗

DOI：
10.1021/acs.bioconjchem.2c00066
发表时间：
2022-04-20
期刊：
BIOCONJUGATE CHEMISTRY
影响因子：
4.7
作者：
Han, Jinghua;Yang, Wei;Huang, Xinglu
通讯作者：
Huang, Xinglu

Achieving enhanced peroxidase-like activity in multimetallic nanorattles

在多金属纳米摇铃中实现增强的过氧化物酶样活性

DOI：
10.1039/d2dt02389j
发表时间：
2022
期刊：
Dalton Transactions
影响因子：
4
作者：
da Silva, Flavia G.;Formo, Eric V.;Camargo, Pedro H.
通讯作者：
Camargo, Pedro H.

Direct nanoscale observations of degassing-induced crystallisation in felsic magmas

长英质岩浆脱气诱导结晶的直接纳米尺度观察

DOI：
10.1007/s00410-022-01900-1
发表时间：
2022
期刊：
Contributions to Mineralogy and Petrology
影响因子：
3.5
作者：
Pistone, Mattia;Formo, Eric;Whittington, Alan G.;Herbst, Thomas;Cottrell, Elizabeth
通讯作者：
Cottrell, Elizabeth

Catalytic Esterification Using Solid Acid Carbon Catalysts Synthesized by Sustainable Hydrothermal and Plasma Sulfonation Techniques