MRI: Acquisition of a High-Resolution Liquid Chromatography-Mass Spectrometer for Environmental Monitoring and Metabolomics Research and Training

MRI：购买高分辨率液相色谱-质谱仪，用于环境监测和代谢组学研究与培训

• 批准号: 1919870
• 负责人: Kurt Pennell
• 金额: $ 48.25万
• 依托单位: Brown University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-15 至 2022-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1919870&HistoricalAwards=false
• 关键词: MRI; Acquisition; Resolution; Liquid; Chromatography

Recent instances of human exposure to environmental contaminants include the situation with lead in Flint, Michigan tap water and per- and polyfluoroalkyl substances (PFAS) in the Cape Fear River Basin, which serves as a drinking water supply for Wilmington, North Carolina. These cases have contributed to a public awakening and recognition about a range of environmental contaminants. This project supports the purchase of a high-resolution mass spectrometer, called the QExactive Orbitrap. The unique capabilities of the QExactive Orbitrap mass spectrometer allow for the separation of thousands of chemicals contained in a single sample and the identification of these chemicals at trace concentrations. This instrument will enable research and training on the measurement of organic contaminants in environmental samples (for example, in soil and water) and biological samples (for example, in blood and urine). The mass spectrometer also will help researchers assess changes in human metabolism in response to contaminant exposure.This project brings together a diverse and active research team to determine the prevalence of contaminants in the environment and to advance our understanding of the effects of chemical exposures on human health. The specific research activities supported by the acquisition of a QExactive Orbitrap mass spectrometer include: (a) identifying metabolic alterations associated with exposure to environmental contaminants, (b) detecting contaminants in soil, water and air samples, (c) measuring the contaminant levels in humans, and (d) identifying biomarkers associated with adverse health outcomes. These activities will support research conducted by undergraduate and graduate students, who will receive personalized training related to instrument operation, data extraction, and analysis. The mass spectrometer will be available to both internal and external researchers and will be used to support environmental monitoring efforts affiliated with local schools, research centers and community organizations.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

最近人类接触环境污染物的实例包括密歇根州弗林特自来水中的铅含量以及开普菲尔河流域的全氟烷基物质和多氟烷基物质（PFAS）的情况，该河流域是北卡罗来纳州威尔明顿的饮用水供应源。 这些案例促使公众觉醒并认识到一系列环境污染物。 该项目支持购买高分辨率质谱仪，称为 QExactive Orbitrap。 QExactive Orbitrap 质谱仪的独特功能可以分离单个样品中包含的数千种化学物质，并识别痕量浓度的这些化学物质。 该仪器将支持环境样品（例如土壤和水）和生物样品（例如血液和尿液）中有机污染物测量的研究和培训。 质谱仪还将帮助研究人员评估人类新陈代谢因污染物暴露而发生的变化。该项目汇集了多元化且活跃的研究团队，以确定环境中污染物的流行程度，并加深我们对化学品暴露对人类影响的了解健康。购买 QExactive Orbitrap 质谱仪支持的具体研究活动包括：(a) 识别与环境污染物暴露相关的代谢变化，(b) 检测土壤、水和空气样本中的污染物，(c) 测量土壤、水和空气样本中的污染物水平人类，以及（d）识别与不良健康结果相关的生物标志物。这些活动将支持本科生和研究生进行的研究，他们将接受与仪器操作、数据提取和分析相关的个性化培训。该质谱仪将可供内部和外部研究人员使用，并将用于支持当地学校、研究中心和社区组织附属的环境监测工作。该奖项反映了 NSF 的法定使命，并通过使用基金会的评估进行评估，认为值得支持。智力价值和更广泛的影响审查标准。