EAGER: Novel family of cellulose acetate fluorescent nanoparticles for bio imaging applications

EAGER：用于生物成像应用的新型醋酸纤维素荧光纳米粒子系列

• 批准号: 1745530
• 负责人: Igor Sokolov
• 金额: $ 8.12万
• 依托单位: Tufts University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2019-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1745530&HistoricalAwards=false
• 关键词: EAGER; Novel; family; cellulose; acetate

Cellulose is one of the most abundant biocompatible materials on earth. Cellulose acetate, viscose, or artificial silk are the most technologically developed and well-characterized derivatives of cellulose, which is completely benign to humans. While various optical materials have been developed from cellulose acetate (CA), optical nanomaterials made of this cellulose derivative are nonexistent. This proposal deals with the development of the first fluorescent nanoparticles and nanofibers made of cellulose acetate (CA), that would make them potentially transformative for biomedical applications.The project will study CA nano-optical properties then evaluate their potential as labels and sensors for biophotonic applications. Initial work demonstrated the presence of donor-acceptor coupling between encapsulated dyes. Encapsulating hydrophobic fluorescent dyes have many advantages such as exceptional photostability. These features suggest the potential of a new platform for developing a whole family of fluorescent nanoparticles and nanosensors for biomedical applications. There is a clear need to address key exploratory questions to reduce the high risk of this transformative approach. For example, photonic properties of encapsulated dyes inside of CA nanoparticles has not been studied. The role of fluorescent and functional molecules in the particle synthesis is unclear. These questions and others will be addressed in the project.

纤维素是地球上最丰富的生物相容性材料之一。醋酸纤维素，粘胶或人造丝是纤维素的技术开发最多，特征良好的衍生物，对人类完全良性。虽然已经从乙酸纤维素（CA）开发了各种光学材料，但该纤维素衍生物制成的光学纳米材料不存在。该提案涉及乙酸纤维素（CA）制成的第一荧光纳米颗粒和纳米纤维的开发，这将使它们具有潜在的生物医学应用的变化性。该项目将研究CA纳米光学特性，然后评估其潜在的潜能，以作为生物体量的标签和传感器申请。最初的工作证明了封装染料之间存在供应器耦合。封装疏水荧光染料具有许多优势，例如特殊的光稳定性。这些功能暗示了一个新平台的潜力，用于开发整个荧光纳米颗粒和用于生物医学应用的纳米传感器。显然需要解决关键的探索性问题，以减少这种变革性方法的高风险。例如，尚未研究Ca纳米颗粒内部染色体的光子性质。荧光和功能分子在颗粒合成中的作用尚不清楚。这些问题和其他问题将在项目中解决。

项目成果

Ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications

• DOI: 10.1016/j.mattod.2018.11.001
• 发表时间: 2019-03-01
• 期刊: MATERIALS TODAY
• 影响因子: 24.2
• 作者: Peng, Berney;Almeqdadi, Mohammad;Sokolov, Igor
• 通讯作者: Sokolov, Igor

Data on ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications

• DOI: 10.1016/j.dib.2018.12.030
• 发表时间: 2019-02-01
• 期刊: DATA IN BRIEF
• 影响因子: 1.2
• 作者: Peng, Berney;Almeqdadi, Mohammad;Sokolov, Igor
• 通讯作者: Sokolov, Igor