EAGER: Development of fluorescent sensors of temperature and iron ion concentrations around magnetic particles under the action of an oscillating magnetic field

EAGER：开发振荡磁场作用下磁性颗粒周围温度和铁离子浓度的荧光传感器

• 批准号: 2110757
• 负责人: Igor Sokolov
• 金额: $ 10.01万
• 依托单位: Tufts University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2110757&HistoricalAwards=false
• 关键词: EAGER; Development; fluorescent; sensors; temperature

The goal of this project is to develop optical sensors to understand the mechanism of treating cancer by hyperthermia (overheating). This promising techniques is performed by first injecting magnetic nanoparticles then heating them with a magnetic field. Hyperthermia treatment is still suffering from multiple side effects, which prevent its broad use. It is currently believed that increased temperature is more toxic for cancer compared to normal tissue. In this project, the investigators will test the hypothesis that the magnetic nanoparticles actively dissolve themself under the action of the magnetic field, thereby adding chemical toxicity, which also helps kill cancer cells. To test this hypothesis, new optical sensors will be developed to measure localized temperature and iron salt concentration around the magnetic particles. The collected knowledge will be used to increase the efficiency of hyperthermia treatment of cancer and eventually decrease the side effects. The project will also contribute to the education and research training of a female graduate student in this multidisciplinary area including nanophotonics, physics, and medicine, and results will be incorporated into “Introduction to scanning probe microscopy” and “Nano and micro mechanics” courses.To understand the mechanism of action of hyperthermia treatment on cancer cells, ultrabright fluorescent ratiometric nanosensors of temperature and iron ions will be developed. A thin fluorescent coating of magnetic particles will be sensitive to the change of temperature and the concentrations of iron ions. Ultrahigh brightness of the photonic sensors will allow detecting the changes in temperature and ionic concentration optically, which is otherwise highly challenging. This technique will aid in the understanding of the action of the oscillating magnetic field on iron oxide magnetic nanoparticles. This understanding is important because magnetic fields are considered not only for hyperthermia treatment of cancer but for various other imaging and drug delivery techniques as well. This work will also shed light on the understanding of the photonic properties of encapsulated dyes inside of nanoporous silica matrix of the proposed nanosensors.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该项目的目标是开发光学传感器来了解热疗（过热）治疗癌症的机制。这种有前途的技术是通过首先注射磁性纳米粒子然后用磁场加热它们进行的。热疗治疗仍然存在多种副作用。目前认为，与正常组织相比，温度升高对癌症的毒性更大，研究人员将测试磁性纳米粒子在磁场作用下主动溶解的假设。添加化学毒性，这也有助于杀死癌细胞。为了验证这一假设，将开发新的光学传感器来测量磁性颗粒周围的局部温度和铁盐浓度，所收集的知识将用于提高癌症热疗的效率。并最终减少副作用，该项目还将有助于女研究生在纳米光子学、物理学和医学等多学科领域的教育和研究培训，其结果将被纳入“扫描探针显微镜简介”和“纳米和微米为了了解热疗对癌细胞的作用机制，将开发温度和铁离子的超亮荧光比例纳米传感器，磁性颗粒的薄荧光涂层将对温度和铁浓度的变化敏感。光子传感器的超高亮度将允许以光学方式检测温度和离子浓度的变化，否则该技术将有助于理解振荡磁场对氧化铁磁性的作用。这种理解很重要，因为磁性不仅被认为可用于癌症领域的热疗，而且还可用于各种其他成像和药物输送技术，这项工作还将有助于理解纳米多孔二氧化硅内部封装染料的光子特性。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。