I-Corps: Silicon Nanocrystals

I-Corps：硅纳米晶体

• 批准号: 1565469
• 负责人: Brian Korgel
• 金额: $ 5万
• 依托单位: University of Texas at Austin
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-10-15 至 2016-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1565469&HistoricalAwards=false
• 关键词: Corps; Silicon; Nanocrystals

Nanomaterials can be designed and created with both imaging and therapeutic function for medical applications. These materials are expected to be important for future personalized medicine. This I-Corps team will explore the use of a new nanomaterials platform of light-emitting silicon nanocrystals as bioimaging markers and therapeutic agents for medicine. Silicon nanocrystals offer unique properties that might be used in humans to provide valuable medical information without toxic side-effects. The I-Corps team will determine the clinical need and market fit for biocompatible silicon nanocrystals. This I-Corps team has developed biocompatible and non-toxic silicon nanocrystals that are bright emitters of near infrared light. The nanocrystals can be dispersed in water, tethered with molecular recognition molecules, or coated with surfactant for introduction into living systems with specifically engineered interactions with different cell types. The potential exists to use these materials for medical imaging and therapeutics. The silicon nanocrystals can be used to generate singlet oxygen or heat to trigger a therapeutic response or to act as a drug-release trigger. In this project, the I-Corps team intends to take the first step towards commercialization by identifying a possible formulation with a specific medical application with commercial potential by conducting market research.

纳米材料可以设计和制造出具有成像和治疗功能的医疗应用。 这些材料预计对未来的个性化医疗非常重要。 I-Corps 团队将探索使用发光硅纳米晶体的新型纳米材料平台作为生物成像标记物和医学治疗剂。 硅纳米晶体具有独特的特性，可用于人类提供有价值的医疗信息，且无毒副作用。 I-Corps 团队将确定生物相容性硅纳米晶体的临床需求和市场契合度。 I-Corps 团队开发了生物相容且无毒的硅纳米晶体，它们是近红外光的明亮发射器。 纳米晶体可以分散在水中，与分子识别分子结合，或涂有表面活性剂，以引入生命系统，与不同细胞类型进行专门设计的相互作用。 这些材料具有用于医学成像和治疗的潜力。 硅纳米晶体可用于产生单线态氧或热量以触发治疗反应或充当药物释放触发器。在该项目中，I-Corps 团队打算通过进行市场研究，确定具有商业潜力的特定医疗应用的可能配方，从而迈出商业化的第一步。