Industrial Scale-up and Prototype Evaluation of Biologically Benign Surface Functinalized Silicon Nanocrystals.

生物良性表面功能化硅纳米晶体的工业放大和原型评估。

• 批准号: 501855-2016
• 负责人: Veinot, Jonathan
• 金额: $ 9.11万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Idea to Innovation
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=608958
• 关键词: Industrial; Scale; up; Prototype; Evaluation

Quantum dots (QDs) are poised to revolutionize medical diagnostics and treatments and have a substantial impact on a wide range of consumer products because of their tailorable size-dependent optical and chemical response. Unfortunately most commercially available QDs contain toxic metals (e.g., cadmium, lead, or indium) that severely limit their market reach. Silicon nanocrystals (SiNCs) are metal-free QDs that possess all of the favorable properties of their toxic metal containing counterparts with the added benefits of elemental abundance, biologically compatibility. Despite the obvious advantages of SiNCs there are few convenient scalable methods for their production and the limited examples of commercially available materials are of poor quality. This proposal requests funds to: i) optimize material production and properties (i.e., increase the scale of this preparative method, optimize functionalization methods to maximize compatibility of SiNCs with water/biological media, optimize and demonstrate the scope of surface exchange reactions, improve photoluminescence), demonstrate applications (i.e., MR imaging, luminescence imaging) while directly comparing SiNC performance with that of key competing technologies, and prepare application/specification documents that will facilitate commercialization.

量子点 (QD) 有望彻底改变医疗诊断和治疗，并且由于其可定制的依赖于尺寸的光学和化学响应而对各种消费品产生重大影响。不幸的是，大多数市售量子点都含有有毒金属（例如镉、铅或铟），这严重限制了它们的市场范围。硅纳米晶体 (SiNC) 是不含金属的量子点，它具有含有毒金属的对应物的所有有利特性，并具有元素丰度和生物相容性等额外优点。尽管 SiNC 具有明显的优势，但其生产却很少有方便的可扩展方法，而且商用材料的例子有限，质量较差。该提案要求资金：i) 优化材料生产和性能（即，扩大这种制备方法的规模，优化功能化方法以最大限度地提高 SiNC 与水/生物介质的兼容性，优化和演示表面交换反应的范围，改善光致发光），展示应用（即 MR 成像、发光成像），同时直接将 SiNC 性能与关键竞争技术进行比较，并准备有助于商业化的应用/规范文件。