Collaborative Research: Planning Grant: I/UCRC for Advanced Mammalian Biomanufacturing Innovation Center (AMBIC)

合作研究：规划补助金：I/UCRC 先进哺乳动物生物制造创新中心 (AMBIC)

• 批准号: 1464280
• 负责人: Kelvin Lee
• 金额: $ 1.15万
• 依托单位: University of Delaware
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1464280&HistoricalAwards=false
• 关键词: Collaborative; Research; Planning; Grant; UCRC

Johns Hopkins University, Clemson University, and the University of Delaware propose to form a new NSF-supported Industrial/University Cooperative Research Center (I/UCRC) entitled the Advanced Mammalian Biomanufacturing Innovation Center (AMBIC) to address current and future challenges faced by US bio-pharmaceuticals manufacturing. The Advanced Mammalian Biomanufacturing Innovation Center (AMBIC) will bring together leading academic, industrial, and government biotechnologists with the goal of advancing cell culture manufacturing innovation at a pre-competitive research level. AMBIC represents a unique opportunity to address technology challenges and bottlenecks in US biopharmaceutical manufacturing by bringing together leading researchers and innovators to implement transformative products and processes that will lead to a stronger, healthier, and more competitive biopharmaceutical industry. In this way, AMBIC will be a critical catalyst towards maintaining national excellence in biopharmaceutical production by focusing on mammalian cell culture issues. The three thrusts of AMBIC are as follows:1. Genome and Cellular Engineering of Mammalian Platform with the goal of developing advanced platforms with improved production capabilities.2.`Omics and Systems Biology for Mammalian Cells with the task of acquiring ?omics data and implementing standards of performance for the mammalian production platform3.Optimizing Bioreactor Control for Improved Cellular Performance with the objective of characterizing metabolic states and implementing advanced controls. This project will support the planning meeting to engage partners from the biopharmaceutical industry and government to participate in AMBIC and develop a research and educational program for the center. A planning meeting will help to identify major research challenges and to design a cutting edge research and educational program in mammalian biomanufacturing. Furthermore, AMBIC will establish and maintain a pipeline of educated and motivated students at all levels for careers in biopharmaceutical manufacturing and development. Collaborations with corporate partners will enable the students to work on the most pressing problems that the industry faces. In addition, AMBIC will serve to engage and excite students from under-represented minority populations to pursue a career in life sciences, engineering, or related STEM fields. Through systems biology analysis, novel cell line development, and bioreactor optimization, AMBIC will provide innovative solutions to improve biomanufacturing efficiencies. These advances will ultimately serve to lower overall health care costs for consumers and make biopharmaceuticals more affordable and available for a greater number of patients.

约翰·霍普金斯大学，克莱姆森大学和特拉华大学建议组建一个新的NSF支持的工业/大学合作研究中心（I/UCRC），名为《高级哺乳动物生物制造创新中心》（AMBIC），以应对当前和未来的挑战，由Bio-us-us-us-pharmaceuticals制造。先进的哺乳动物生物制造创新中心（AMBIC）将召集领先的学术，工业和政府生物技术医生，以便在竞争力的研究级别上推进细胞文化制造创新。 Ambic是一个独特的机会，可以通过将领先的研究人员和创新者汇集到实施变革性的产品和流程，从而导致更强大，更健康，更具竞争力的生物制药行业，以应对美国生物制药制造的技术挑战和瓶颈。 这样，Ambic将通过专注于哺乳动物细胞培养问题来维持生物制药生产的全国性卓越生产。 Ambic的三个推力如下：1。哺乳动物平台的基因组和细胞工程的目的是开发具有提高生产能力的先进平台。该项目将支持计划会议，以吸引来自生物制药行业和政府的合作伙伴参与Ambic并为该中心制定研究和教育计划。 计划会议将有助于确定重大的研究挑战，并在哺乳动物生物制造中设计尖端的研究和教育计划。 此外，Ambic将在各个层面上建立并维护受过教育和积极进取的学生的渠道，以实现生物制药制造和开发的职业。 与公司合作伙伴的合作将使学生能够解决行业面临的最紧迫问题。 此外，Ambic将有助于吸引和激发代表性不足的少数群体的学生，从而从事生命科学，工程或相关STEM领域的职业。通过系统生物学分析，新型细胞系发育和生物反应器优化，Ambic将提供创新的解决方案，以提高生物制造效率。 这些进步最终将有助于降低消费者的总体医疗保健成本，并使生物制药更实惠，并为更多的患者提供。