EAGER: The International CHO Genome Community Project

EAGER：国际 CHO 基因组社区项目

• 批准号: 1124627
• 负责人: Kelvin Lee
• 金额: $ 10万
• 依托单位: University of Delaware
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1124627&HistoricalAwards=false
• 关键词: EAGER; International; CHO; Genome; Community

The overall objective for this EAGER proposal is to develop a framework to support the international Chinese hamster ovary (CHO) cell community's effort to move into the genomeera. CHO cells are currently the most widely used mammalian cell line for biopharmaceutical production. Nearly 70% of all recombinant biotherapeutics, yielding a global market of nearly $100 billion per year, are produced in CHO cells. Biopharmaceutical production will continue to provide the pharmaceutical industry with tremendous growth in the next several years, enabling continued research into new medical treatments and the expansion of manufacturing facilities. Unfortunately, efforts to improve the system using metabolic engineering and other scientific and engineering methodologies have lagged due to the absence of a genome and communitygenome framework. As a result, this project will implement the infrastructure to pursue two specific aims for support of the international CHO community:Specific Aim #1:Develop an information technology (IT) - infrastructure to support the sharing of genome-scale data and tools for the CHO biotechnology community and provide a forum where the CHO biotechnology community can interact and synergize on-line.Specific Aim #2:Educate graduate students on the use of bioinformatics to implement and analyze the CHO genome and enhance specific productivity and product quality using new webbased tools of importance to the CHO community.The intellectual merit of this proposal results from the development of a one-stop website portal to support the community. As part of the establishment of this portal, a number of bioinformatic tools will need to be employed to seamlessly migrate existing genome-scale datasets into a common interface.The broader impact of this proposal relates to the important impact this effort will have on the entire international CHO biotechnology community. Partners from a wide range of international entities including academic, government, and industrial scientists, have come together to support the CHO genome community by providing resources, expertise, and data. Additional impact will come from the education of graduate students working on the project who will closely interface with industrial scientists and from workforce development activities for the industrial community.

这项渴望提出的总体目标是开发一个框架，以支持国际中国仓鼠卵巢（CHO）细胞社区努力进入Genomeera。 CHO细胞目前是用于生物药物生产的最广泛使用的哺乳动物细胞系。在CHO细胞中，所有重组生物治疗剂中有近70％每年产生近1000亿美元的全球市场。生物制药生产将在未来几年内继续为制药行业提供巨大的增长，从而继续研究新的医疗治疗和制造设施的扩展。不幸的是，由于缺乏基因组和社区基因组框架，使用代谢工程以及其他科学和工程方法改善系统的努力已落后。结果，该项目将实施基础架构，以追求支持国际CHO社区的两个具体目的：特定目的1：开发信息技术（IT） - 基础架构，以支持共享基因组规模的数据和CHO Biotechnology社区的共享，并提供一个论坛，并在Cho Biotechnology社区上进行互动和协同培训，并在线上进行交互。并使用对Cho社区的重要重要性工具来分析CHO基因组并提高特定的生产力和产品质量。该建议的智力优点是由开发一站式网站门户网站来支持社区的智力优点。作为建立该门户的一部分，需要使用许多生物信息学工具将现有的基因组规模数据集迁移到一个共同的界面中。该提案的更广泛影响与这项工作对整个国际Cho Biotechnology社区的重要影响有关。来自包括学术，政府和工业科学家在内的各种国际实体的合作伙伴已经聚集在一起，通过提供资源，专业知识和数据来支持CHO基因组社区。额外的影响将来自从事该项目的研究生的教育，他们将与工业科学家和工业社区的劳动力发展活动紧密接触。