I-Corps: Optimized OCT-Video Imaging in a Handheld Scanning Otoscope

I-Corps：手持式扫描耳镜中优化的 OCT 视频成像

• 批准号: 1445170
• 负责人: Stephen Boppart
• 金额: $ 5万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1445170&HistoricalAwards=false
• 关键词: Corps; Optimized; OCT; Video; Imaging

Ear Nose Throat (ENTs) specialists and other healthcare professionals that diagnose and treat middle ear disease need to know if the patient has an infection, whether that infection is bacterial or viral, and determine some measure of the severity of the infection. They need to be able to make this assessment quickly because their interpretation of the middle ear health is the basis for significant interventional treatment, such as the prescription of antibiotics or decision to perform interventional surgery to minimize pain, illness, hearing loss, and delays in speech and language development. Despite the obvious importance and prevalence of this disease, the clinical gold standard for diagnosing ear infections is essentially a magnifying glass. The otoscope is a tool healthcare professionals use to evaluate middle ear health. The problem is that the otoscope only allows visualization of the surface of the eardrum, when the disease actually takes place in the middle ear. This team has developed a handheld medical device that can not only view the surface of the eardrum, but can also see through the eardrum and into the middle ear. The proposed improved diagnostics will lead to better clinical outcomes due to better management of antibiotics and interventional surgery.The proposed technology uses harmless near-infrared light to produce three-dimensional images of the eardrum and middle ear contents. This provides physicians access to a wealth of new information, such as eardrum thickness, which has shown to vary with infection severity, effusion purulence, which is a strong indicator of the degree of infection, and most importantly, the presence or absence of a bacterial biofilm, which has been linked to chronic recurrent cases of ear infection that are generally resistant to antibiotic therapy. With 3-D information, quantitative measures and metrics can be visualized and recorded for objective diagnoses and longitudinal monitoring of therapeutic interventions. The device is used in the same way that a traditional otoscope is used, and since it can provide objective measurements, it allows a technician or nurse to obtain the same quality of diagnostic information as that of an experienced physician.

诊断和治疗中耳疾病的耳鼻喉喉咙（ENT）专家和其他医疗保健专业人员需要知道患者是否感染，无论该感染是细菌还是病毒，并确定感染严重程度的一定程度。他们需要能够迅速进行评估，因为他们对中耳健康的解释是进行大量介入治疗的基础，例如处方抗生素或决定进行介入的手术以最大程度地减少疼痛，疾病，听力损失以及言语和语言发展的延迟。尽管这种疾病的重要性和患病率显而易见，但诊断耳朵感染的临床金标准本质上是放大镜。耳镜是医疗保健专业人员用于评估中耳健康的工具。问题在于，当疾病实际发生在中耳中时，耳镜仅允许可视化耳膜表面。 该团队开发了一种手持式医疗设备，不仅可以查看耳膜的表面，而且可以通过耳膜看到并进入中耳。拟议的改进诊断方法将由于更好地管理抗生素和介入手术，从而导致更好的临床结果。该技术使用无害的近红外光线来生成耳膜和中耳内容物的三维图像。这使医生可以访问大量新信息，例如耳膜厚度，这些信息与感染的严重程度，积液纯度不同，这是感染程度的有力指示，最重要的是，存在或不存在细菌性生物膜，这与抗衰老毒素的持续性感染相关。 有了3-D信息，可以将定量措施和指标可视化和记录，以进行客观诊断和治疗干预措施的纵向监测。该设备的使用方式与使用传统的耳镜相同，并且由于它可以提供客观的测量值，因此它允许技术人员或护士获得与经验丰富的医生相同的诊断信息质量。