Collaborative Research: IDBR: The Nanosizer: A New Nanolithographic Tool for Preparing Combinatorial Arrays in Situ

合作研究：IDBR：Nanosizer：一种用于原位制备组合阵列的新型纳米光刻工具

• 批准号: 1340038
• 负责人: Adam Braunschweig
• 金额: $ 20.43万
• 依托单位: University of Miami
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1340038&HistoricalAwards=false
• 关键词: Collaborative; Research; IDBR; Nanosizer; New

The Directorate for Biological Sciences through their Instrument Development for Biological Research program and the Division of Chemistry through Chemical Measurement and Imaging support Prof. Chad A. Mirkin, Northwestern University, and Prof. Adam B. Braunschweig, New York University, to develop a new instrument to fabricate nanoarrays of biologically active probes. This new instrument, termed the Nanosizer, will produce combinatorial arrays of oligonucleotides, oligopeptides, and many other biologically active small molecules with sub-100 nanometer feature diameters over large areas (10's of cm2); thereby achieving order of magnitude improvements in feature size, production rate, and cost over current technologies and providing access to fundamental biological experiments that could not otherwise be undertaken. This goal will be achieved by combining massively-parallel tip based nanolithography strategies with new microfluidic designs, and photochemically activated combinatorial surface syntheses. Following proof-of-concept demonstrations, the instrument will be systematically optimized with regard to chemical kinetics and reaction times and automated to facilitate instrument operation. This interdisciplinary project uniquely combines elements of chemistry, engineering, and materials science to create an instrument capable of producing arbitrary patterns of soft matter over large areas, where the chemical composition and position of every feature can be controlled precisely.The new instrument developed in the context of this collaborative proposal will address a major problem for industrial and academic researchers by providing a facile method for preparing arbitrary nanopatterns of biologically active probes. Moreover, the Directorate of Biological Research will sustain Prof. Mirkin and Prof. Braunschweig's outreach activities, including financial support of summer students from minority-serving four year colleges to assist in this project during the summer and a range of other outreach activities that increase scientific awareness at eminent institutions including the Museum of Science and Industry in Chicago, the Metropolitan Museum of Art in New York, and the Young Women's Leadership School of East Harlem.

生物科学局通过其生物学研究计划的仪器开发以及化学测量和成像支持Chad A. Mirkin教授，西北大学和纽约大学Adam B. Braunschweig教授，开发一种制造生物学活跃探测器的纳米阵列的新工具。该新仪器称为纳米剂，将产生寡核苷酸，寡肽和许多其他生物活性的小分子的组合阵列，其在大面积（10 is of CM2）上具有低100纳米特征直径；从而比当前技术的特征大小，生产率和成本方面取得了数量级的改善，并提供了无法进行基本生物学实验的访问权限。将大规模平行尖端的纳米光刻策略与新的微流体设计和光化学激活的组合表面合成结合在一起，可以实现此目标。概念验证示范后，该仪器将在化学动力学和反应时间系统上进行系统优化，并自动化以促进仪器操作。这个跨学科的项目独特地结合了化学，工程和材料科学的要素，创建了一种能够在大面积上产生任意的软物质模式的工具，在大面积上，每个特征的化学组成和位置都可以精确地控制。在此协作方面，在此协作方面为工业和学术研究人员提供了一个为生物提供一个可靠的nanop inanobity nan nan nan nan nan nan nan nan nan nan nan nan nan nan nan nan nan nan nop sop的新工具。 Moreover, the Directorate of Biological Research will sustain Prof. Mirkin and Prof. Braunschweig's outreach activities, including financial support of summer students from minority-serving four year colleges to assist in this project during the summer and a range of other outreach activities that increase scientific awareness at eminent institutions including the Museum of Science and Industry in Chicago, the Metropolitan Museum of Art in New York, and the Young Women's Leadership School of East Harlem.