I-Corps: Synthetic secretions

I-Corps：合成分泌物

• 批准号: 2223758
• 负责人: Adam Braunschweig
• 金额: $ 5万
• 依托单位: Research Foundation CUNY - Advanced Science Research Center
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-01 至 2022-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2223758&HistoricalAwards=false
• 关键词: Corps; Synthetic; secretions

The broader impact/commercial potential of this I-Corps project is the development of synthetic mucins (analogs of mucus) to impact the skincare, healthcare, and materials industries. Initially, the synthetic mucus will be explored as anti-aging, moisturizing skincare ingredients, and will replace natural mucins derived from animals. Importantly, the synthetic methods may allow for the synthesis of diverse mucin analogs, with varying material and biological properties. Following the development of synthetic mucins for skincare, the team will develop materials for transdermal delivery, biocompatible lubrication, and surgical adhesives. The synthetic analogs of mucus can aid in understanding the role of mucus in digestive, respiratory, and immune systems. The additional broader impacts include launching a new US-based, high-tech material manufacturing company, creating new markets for mucins, and providing nontoxic skincare, healthcare, and biomedical solutions, where no other adequate alternative exists.This I-Corps project is based on the development of synthetic materials that mimic the structures and properties of animal mucus. Animals secrete different mucus for a variety of functions, including lubrication, hydration, and adhesion. The team has recently developed a synthetic analog of snail mucin that is a substitute for the snail mucus filtrate currently used in hydrating skincare products. The synthetic mucin is a water-soluble glycosylated polypeptide that can be produced on the kilogram scale. Currently, synthetic mucins are only produced on the milligram scale or have chemical compositions that do not fully mimic the composition or properties of the natural mucins. The proposed technology reresenets a scalable synthesis of a glycosylated polypeptide that re-creates all the salient structural and physical characteristics of snail mucins.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该I-Corps项目的更广泛的影响/商业潜力是开发合成粘蛋白（粘液的类似物），以影响护肤，医疗保健和材料行业。最初，合成粘液将作为抗衰老，保湿的护肤成分探索，并取代自然粘蛋白衍生自动物。重要的是，合成方法可以允许具有不同材料和生物学特性的多种粘蛋白类似物的合成。在开发护肤合成粘蛋白后，该团队将开发用于透皮递送，生物相容性润滑和手术粘合剂的材料。粘液的合成类似物可以帮助理解粘液在消化，呼吸和免疫系统中的作用。额外的更广泛的影响包括成立了一家新的基于美国的高科技材料制造公司，为粘蛋白创建新市场，并提供无毒的护肤，医疗保健和生物医学解决方案，在该解决方案中不存在其他适当的替代方案。该I-Corps项目基于模拟结构的合成材料的开发，这些材料模拟了结构和物业的属性和物业。动物分泌不同的粘液，以提供多种功能，包括润滑，水合和粘附。该团队最近开发了一种蜗牛粘蛋白的合成类似物，该类似物是当前用于保湿护肤产品的蜗牛粘液滤液的替代品。合成粘蛋白是一种水溶性糖基化多肽，可以在千克尺度上产生。目前，合成粘蛋白仅以毫克量表产生，或具有无法完全模仿天然粘蛋白的组成或特性的化学成分。拟议的技术重新培训是糖基化多肽的可扩展合成，重新创建了Snail Mucins的所有显着结构和物理特征。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的智力功能和更广泛影响的评估来进行评估的支持，这是值得的。