Novel Approaches to Heterocyclic Synthons

杂环合成子的新方法

基本信息

批准号：
1266365
负责人：
Jon Njardarson
金额：
$ 42万
依托单位：
University of Arizona
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-15 至 2016-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1266365&HistoricalAwards=false
关键词：
Novel Approaches Heterocyclic Synthons

项目摘要

In this project funded by the Chemical Synthesis Program of the Chemistry Division, Professor Jon T. Njardarson of the Department of Chemistry and Biochemistry at The University of Arizona will develop useful new heterocyclic reactions. The proposed new reactions fall into two reaction classes: 1) new catalytic ring expansions and 2) new anionic cascades. Asymmetric variations of the most significant reactions will also be studied. In addition to delivering useful new methods, the proposed research will make contributions to the emerging field of chiral counterion catalysis as well as expanding the knowledge of what makes an ideal anionic hopping group and how to most effectively use it for anionic cascades. Heterocyclic compounds are one of the more important structural scaffolds found in pharmaceuticals while also playing key roles in numerous other material applications. The proposed new heterocyclic methods will provide researchers in the pharmaceutical industry and other fields as well as academia with new and complementary approaches for building important structures. In addition, this project will provide excellent training of undergraduate and graduate students. Particularly noteworthy deliverables, which the students associated with these projects are involved in, are unique freely accessible educational/research tools such as Disease Focused Pharmaceutical posters, Top200 Drug posters and the free app/website Chemistry By Design. These new internet tools provide access to learning about organic chemistry and its importance to society.

在化学部化学综合计划资助的该项目中，亚利桑那大学化学和生物化学系的乔恩·T·恩贾达森教授将发展有用的新杂环反应。提出的新反应分为两个反应类别：1）新的催化环膨胀和2）新的阴离子级联反应。还将研究最重要的反应的不对称变化。除了提供有用的新方法外，拟议的研究还将为手性反式催化的新兴领域做出贡献，以及扩大使理想的阴离子跳跃组以及如何最有效地将其用于阴离子级联反应的知识。杂环化合物是药品中最重要的结构支架之一，同时在许多其他材料应用中也发挥关键作用。拟议的新杂环方法将为制药行业和其他领域的研究人员以及学术界提供新的和互补的方法来建立重要结构。此外，该项目将为本科生和研究生提供出色的培训。与这些项目相关联的学生特别值得注意的可交付成果是独特的自由访问的教育/研究工具，例如以疾病为中心的药品海报，Top200药物海报和免费设计的App/网站化学。这些新的互联网工具提供了学习有机化学及其对社会重要性的访问。