Novel Approaches to Heterocyclic Synthons

杂环合成子的新方法

• 批准号: 0848324
• 负责人: Jon Njardarson
• 金额: $ 39万
• 依托单位: Cornell University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0848324&HistoricalAwards=false
• 关键词: Novel; Approaches; Heterocyclic; Synthons

This project is focused on developing useful new catalytic ring forming reactions. A detailed plan is put forth to utilize mechanistic insights to design new catalysts for the ring expansion of strained heterocyclic synthons. The information gained from these catalyst design and development studies will be used to build chiral variants of the optimal ligand frameworks. The resulting new chiral catalysts will be used for asymmetric desymmetrizations and kinetic resolutions. Concurrently, new and efficient synthetic routes for assembling these heterocyclic synthons will be developed. This will be accomplished in one pot by adding carbon nucleophiles to uniquely activated carbonyl electrophiles. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Jon T. Njardarson of the Department of Chemistry and Chemical Biology at Cornell University. Professor Njardarson's research efforts revolve around the development of new and useful methods for building valuable heterocyclic frameworks. Successful advancement of these new synthetic methods will provide access to a wide range of important heterocyclic products, which will benefit researchers both in academia and the pharmaceutical industry.

该项目的重点是开发有用的新催化环形成反应。提出了一个详细的计划来利用机械洞察力设计新的催化剂，以扩展应变的异环合成子。从这些催化剂设计和开发研究中获得的信息将用于构建最佳配体框架的手性变体。由此产生的新手性催化剂将用于不对称的对称性和动力学分辨率。同时，将开发用于组装这些杂环合成子的新的和高效的合成途径。这将在一个锅中通过在独特活化的羰基亲电的含量中添加碳核试剂来完成。有了这个奖项，有机和大分子化学计划正在支持康奈尔大学化学与化学生物学系的Jon T. Njardarson教授的研究。 Njardarson教授的研究工作围绕着建立有价值的杂环框架的新有用方法的发展。这些新的合成方法的成功发展将为各种重要的杂环产品提供访问，这将使学术界和制药行业的研究人员受益。