New Class of Anionic Cascade Reactions for Organic Synthesis

用于有机合成的新型阴离子级联反应

基本信息

批准号：
1565500
负责人：
Jon Njardarson
金额：
$ 45万
依托单位：
University of Arizona
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2016
资助国家：
美国
起止时间：
2016-05-01 至 2019-05-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1565500&HistoricalAwards=false
关键词：
New Class Anionic Cascade Reactions

项目摘要

The Chemical Synthesis Program of the NSF Chemistry Division supports the research of Professor Jon T. Njardarson in the Department of Chemistry and Biochemistry at the University of Arizona. Heterocyclic compounds are one of the more important structural scaffolds found in pharmaceuticals while also playing key roles in numerous other material applications. Professor Njardarson and his students develop useful new cascade reactions to make pharmaceuticals. For each one of these new cascade reactions, two simple and readily accessible building blocks are brought together in such a way that valuable complex chiral products result. In addition, this project provides excellent training of undergraduate and graduate students. Particularly noteworthy deliverables, which the students associated with these projects are involved in, are unique freely accessible educational/research tools such as pedagogical tools for structure elucidation, the free mobile app/website Chemistry By Design and, novel pharmaceutical structure analyses. The new heterocyclic methods developed in this award provide researchers in the pharmaceutical industry with new and complementary approaches for building important structures. Through the use of cascade reactions, the researchers make innovative contributions to the asymmetric syntheses of valuable heterocyclic ring structures while establishing new knowledge in the areas of a) anionic isomerizations, b) anion accelerated rearrangements, c) ring expansion reactions, d) strain assisted rearrangements, and e) asymmetric dipolar cycloaddition reactions. The many reactions emerging from this research program open the door for researchers in academia and industry to develop useful new blueprints for their target oriented synthesis pursuits. These new classes of reactions, which employ bi-functional nucleophiles, promise to be of broad scope and highly tunable. Particular focus is on elucidating and understanding the reaction mechanisms so that the resulting knowledge foundation can aid in designing new reactions and opening new avenues of investigation. These new educational products provide students, researchers and the public with new opportunities to learn about organic chemistry and its importance to society.

NSF化学部的化学合成计划支持亚利桑那大学化学和生物化学系Jon T. Njardarson教授的研究。杂环化合物是药品中最重要的结构支架之一，同时在许多其他材料应用中也发挥关键作用。 Njardarson教授和他的学生会产生有用的新级联反应，以制造药物。对于这些新的级联反应中的每一个，将两个简单且易于访问的构建块汇总在一起，以至于产生有价值的复杂手性产品。此外，该项目还为本科生和研究生提供了出色的培训。与这些项目相关联的学生特别值得注意的可交付成果是独特的自由访问的教育/研究工具，例如用于结构阐明的教学工具，设计的免费移动应用/网站化学以及新颖的药品结构分析。该奖项中开发的新杂环方法为制药行业的研究人员提供了建立重要结构的新方法和互补方法。 Through the use of cascade reactions, the researchers make innovative contributions to the asymmetric syntheses of valuable heterocyclic ring structures while establishing new knowledge in the areas of a) anionic isomerizations, b) anion accelerated rearrangements, c) ring expansion reactions, d) strain assisted rearrangements, and e) asymmetric dipolar cycloaddition reactions.该研究计划中出现的许多反应为学术界和行业的研究人员开发了为目标综合追求开发有用的新蓝图。这些采用双官能亲核试剂的新反应有望具有广泛的范围且高度可调。特别的重点是阐明和理解反应机制，以便由此产生的知识基础可以帮助设计新的反应并开放新的研究途径。这些新的教育产品为学生，研究人员和公众提供了了解有机化学及其对社会重要性的新机会。