CCI Phase 1: Center for Sustainable Nanotechnology

CCI 第一阶段：可持续纳米技术中心

• 批准号: 1240151
• 负责人: Robert Hamers
• 金额: $ 175万
• 依托单位: University of Wisconsin-Madison
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-15 至 2015-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1240151&HistoricalAwards=false
• 关键词: CCI; Phase; Center; Sustainable; Nanotechnology

Members of this Center for Chemical Innovation (CCI) will collaborate to understand, predict, and control the specific chemical and physical interactions between nanomaterial surfaces and living systems via a molecular level, chemistry-centered approach. Chemically stable nanoparticles having precisely controlled compositions, sizes, shapes, and surface functionalizations will be employed to investigate how they interact with lipid bilayers and with model organisms, toward the goal of understanding the factors influencing the routes by which nanoparticles enter biological systems. Experiments will use lipid bilayers as model systems for biological membranes, Shewanella oneidensis as a single-cell model, and Daphnia magna as a model whole organism. The resulting molecular level changes in gene expression and metabolism will be characterized and used as biomarkers to evaluate biological responses induced by different nanoparticles and surface functionalizations. These biological responses will in turn be used to inform the design and synthesis of nanoparticles having reduced adverse biological impacts. State-of-the-art analytical approaches, including nonlinear optical spectroscopies and genome sequencing tools, will be developed and used to characterize the interaction of functionalized nanoparticles with cells and simple organisms at the molecular level. These results will be informed by concurrent computational studies to provide fundamental insights into nanoparticle-biological interactions and to develop models with which to evaluate future nanomaterials. The research of this CCI will ultimately contribute to the use of nanomaterials for societal benefit in a sustainable manner by leading to the development of nanomaterials with reduced environmental impact. The research will also provide enhanced training of graduate students in interdisciplinary science and the societal impact of nanotechnology. Graduate and undergraduate students will receive training in scientific and technological innovation that will help translate scientific results into economic benefit and other forms of societal impact. The CCI researchers will integrate their research on the sustainable nanotechnologies with educational and outreach activities to develop a program for informing and enhancing citizen engagement in nanotechnology and sustainability science using social media. CCI participants will also engage with teachers to develop K-12 and introductory level university science modules on the chemistry of safe and sustainable nanomaterials. Faculty and students of the CCI will engage with faculty and students at regional minority-serving institutions to increase participation from underrepresented groups via academic-year and summer research programs.The Centers for Chemical Innovation (CCI) Program supports research centers that can address major, long-term fundamental chemical research challenges that have a high probability of both producing transformative research and leading to innovation. These Centers will attract broad scientific and public interest by sharing the results of their approach to this challenging question.

该化学创新中心 (CCI) 的成员将合作通过分子水平、以化学为中心的方法来理解、预测和控制纳米材料表面与生命系统之间的特定化学和物理相互作用。具有精确控制的成分、尺寸、形状和表面功能化的化学稳定的纳米颗粒将用于研究它们如何与脂质双层和模型生物体相互作用，以期了解影响纳米颗粒进入生物系统的途径的因素。实验将使用脂质双层作为生物膜的模型系统，使用希瓦氏菌作为单细胞模型，使用大型水蚤作为整个生物体模型。由此产生的基因表达和代谢的分子水平变化将被表征并用作生物标志物，以评估不同纳米粒子和表面功能化诱导的生物反应。这些生物反应反过来将用于指导纳米颗粒的设计和合成，从而减少不利的生物影响。将开发并使用最先进的分析方法，包括非线性光学光谱和基因组测序工具，以在分子水平上表征功能化纳米颗粒与细胞和简单生物体的相互作用。这些结果将通过并行计算研究提供信息，为纳米颗粒-生物相互作用提供基本见解，并开发用于评估未来纳米材料的模型。该 CCI 的研究最终将通过开发减少环境影响的纳米材料，为以可持续的方式利用纳米材料造福社会做出贡献。该研究还将加强研究生在跨学科科学和纳米技术社会影响方面的培训。研究生和本科生将接受科技创新培训，这将有助于将科学成果转化为经济效益和其他形式的社会影响。 CCI 研究人员将把他们对可持续纳米技术的研究与教育和外展活动结合起来，制定一项计划，利用社交媒体宣传和加强公民对纳米技术和可持续科学的参与。 CCI 参与者还将与教师合作开发有关安全和可持续纳米材料化学的 K-12 和入门级大学科学模块。 CCI 的教职员工和学生将与地区少数族裔服务机构的教职员工和学生合作，通过学年和暑期研究计划来增加代表性不足群体的参与。化学创新中心 (CCI) 计划支持研究中心，这些研究中心可以解决主要、长期的基础化学研究挑战很有可能产生变革性研究并导致创新。这些中心将通过分享他们解决这一挑战性问题的方法的结果，吸引广泛的科学和公众的兴趣。