GOALI/Collaborative Research: Functionalized Nanodiamond Reinforced Biopolymers for Microporous Surgical Fixation Devices

GOALI/合作研究：用于微孔手术固定装置的功能化纳米金刚石增强生物聚合物

• 批准号: 0927963
• 负责人: Jack Zhou
• 金额: $ 41.81万
• 依托单位: Drexel University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0927963&HistoricalAwards=false
• 关键词: GOALI; Collaborative; Research; Functionalized; Nanodiamond

The objective of this award is to explore new composite nano-manufacturing methods to enhance mechanical integrity of biopolymers and to investigate a new micro porous structure which will assist in bioactive material delivery in surgical devices. The approach will be: 1. Conduct biomaterials and nano-diamond (ND) composite research to optimize the polymer/ND interface and mass production technique to manufacture ND reinforced biopolymers. 2. Identify suitable structural and bioactive materials for a strong fixation device body and efficient bone/tissue healing and growth. 3. Research on a new technique: gradient cellular structure to generate bio-reagent storage and passage micro pores to not only assure the device mechanical strength but also assist in bioactive materials delivery. 4. Conduct various mechanical and biological testing to find, control, optimize and integrate all required functionalities for the surgical device.The benefits and broader impacts of this research will be: Provide an innovative way to increase the mechanical integrity of biomaterials and replace current passive orthopedic surgery devices with active devices; a strong relationship with Arthrex, Inc. will be built for the new technology development and transfer; three doctoral students and two senior design teams will be trained; engaging students with design projects in nanomanufacturing, bioactive fixation devices and bio-reagents delivery. The project will be used in outreach workshops for local high school and community college students, including many underrepresented minority students to showcase high-tech nanomanufacturing and surgical engineering applications.

该奖项的目的是探索新的复合纳米制造方法，以增强生物聚合物的机械完整性，并研究一种新的微量多孔结构，该结构将有助于手术设备中的生物活性材料递送。该方法将是：1。进行生物材料和纳米钻石（ND）复合研究，以优化聚合物/ND界面和质量生产技术，以生产ND增强的生物聚合物。 2。确定适合的结构和生物活性材料，以实现强固定装置的身体以及有效的骨/组织愈合和生长。 3。对一种新技术的研究：梯度细胞结构生成生物储存和通道微孔，不仅可以确保设备机械强度，而且还有助于生物活性材料的递送。 4.进行各种机械和生物学测试以查找，控制，优化和整合手术设备的所有必需功能。这项研究的好处和更广泛的影响将是：提供一种创新的方式来增加生物材料的机械完整性并替代当前的被动性。带有主动装置的骨科手术设备；与Arthrex，Inc。建立牢固的关系，将为新技术开发和转移建立；将对三名博士生和两个高级设计团队进行培训；吸引学生从事纳米制造，生物活性固定设备和生物运输交付的设计项目。该项目将用于当地高中和社区大学生的外展研讨会，其中包括许多代表性不足的少数族裔学生，以展示高科技纳米制造和外科工程应用。