GOALI/Collaborative Research: Design and Manufacturing of Bioactive Surgical Fixation Devices Using Injection Molding of Gradient Cellular Structures

GOALI/合作研究：利用梯度细胞结构注射成型设计和制造生物活性手术固定装置

• 批准号: 0800735
• 负责人: Jack Zhou
• 金额: $ 36.05万
• 依托单位: Drexel University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0800735&HistoricalAwards=false
• 关键词: GOALI; Collaborative; Research; Design; Manufacturing

The research objective of this Grant Opportunity for Academic Liaison with Industry (GOALI) Collaborative Research project is to investigate novel surgical fixation devices (screw, anchor, plate, pin, staple, etc.) that not only secure a graft in place, but incorporate bioactive materials such as growth factors, drugs, and cells, intended to promote bone tissue growth. The new devices can eliminate painful secondary operations, adverse effects of permanent implants, and the lack of bioactive features in existing surgical fixation devices. The research addresses challenges in biocompatible, biodegradable and bioactive materials for surgical fixation devices and investigates a new delivery method for bio-reagents through the surgical devices. The approach will be: 1. Identify suitable structural and bioactive materials for a strong fixation device body and efficient bone-tissue healing and growth. 2. Design a new bioactive interference screw, as a specific example and application with required mechanical integrity and bioactivity. 3. Explore a new technique, gradient cellular structure (GCS), to create interconnective porous structure to control screw mechanical strength and assist in bioactive materials delivery. 4. Through testing to find, control, optimize and integrate all required functionalities such as mechanical integrity, material degradation rate, and bioactive reagents delivery rate.If successful, the benefits and broader impacts of this research will be: to replace current passive orthopedic surgery devices with active devices, i.e. the surgical devices not only serve fixation and support purposes but also have curing, healing and tissue-promoting biological functions; a long term research and educational relationship with Arthrex, Inc. will be built for the new technology development and transfer; three doctoral students and two senior design teams will be trained; three project-based learning modules will be created to strengthen the undergraduate mechanical and biomedical engineering curricula, engaging students with design projects in bioactive fixation devices and bio-reagents delivery. New findings from the research will be disseminated in professional journals and at conferences. The project will also be used in specially designed outreach workshops for local high school and community college students, including many underrepresented minority students to showcase high-tech mechanical and polymer engineering applications in biotechnology.

这项学术与工业联络资助机会 (GOALI) 合作研究项目的研究目标是研究新型手术固定装置（螺钉、锚钉、板、销钉、U形钉等），这些装置不仅将移植物固定到位，而且将移植物固定在适当的位置。生物活性材料，如生长因子、药物和细胞，旨在促进骨组织生长。新装置可以消除痛苦的二次手术、永久植入物的不利影响以及现有手术固定装置缺乏生物活性特征。该研究解决了手术固定装置的生物相容性、生物可降解性和生物活性材料的挑战，并研究了通过手术装置输送生物试剂的新方法。该方法将是： 1. 确定合适的结构和生物活性材料，用于坚固的固定装置主体和有效的骨组织愈合和生长。 2. 设计一种新型生物活性干涉螺钉，作为具有所需机械完整性和生物活性的具体示例和应用。 3.探索一种新技术，梯度细胞结构（GCS），以创建互连的多孔结构来控制螺杆机械强度并协助生物活性材料的输送。 4. 通过测试寻找、控制、优化和集成所有所需的功能，如机械完整性、材料降解率和生物活性试剂输送率。如果成功，这项研究的好处和更广泛的影响将是：取代当前的被动骨科手术具有主动装置的器械，即手术器械不仅具有固定和支撑的作用，还具有治愈、愈合和促进组织的生物学功能；将与 Arthrex, Inc. 建立长期研究和教育关系，以促进新技术的开发和转让；培养博士生3名，高级设计团队2名； 将创建三个基于项目的学习模块，以加强本科机械和生物医学工程课程，让学生参与生物活性固定装置和生物试剂输送的设计项目。研究的新发现将在专业期刊和会议上传播。 该项目还将用于专门为当地高中和社区学院学生（包括许多代表性不足的少数族裔学生）设计的外展研讨会，展示高科技机械和聚合物工程在生物技术中的应用。