GOALI/Collaborative Research: Instabilities and Local Strains in Engineered Cartilage Scaffold

GOALI/合作研究：工程软骨支架的不稳定性和局部应变

• 批准号: 2129776
• 负责人: Nikolaos Bouklas
• 金额: $ 50万
• 依托单位: Cornell University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2129776&HistoricalAwards=false
• 关键词: GOALI; Collaborative; Research; Instabilities; Local

This Grant Opportunity for Academic Liaison with Industry (GOALI) collaborative research project will focus on the mechanical properties and deformation of cartilage scaffolds under external loads. Soft porous scaffolds are commonly used to promote cell growth for therapeutic applications in the repair and regeneration of different tissues, including cartilage and bone. The porosity of these scaffolds facilitates cell growth and the transport of nutrients. The mechanical function of such soft implants during the early stage of implantation is dominated by the scaffold that has to carry the applied load and maintain the integrity of cells within its pores. Structural instabilities, often encountered in soft porous materials, can both compromise the mechanical function of the scaffolds as well as damage the encapsulated cells. The research outcomes will advance national health and improve the quality of life for millions of people by transforming engineered cartilage scaffolds in order to maintain implant functionality, prevent cell death, and thus increase the probability of a successful implantation procedure. Furthermore, this collaborative project aims to engage several high-school and undergraduate students from underrepresented minorities through summer outreach programs at Cornell University and Johns Hopkins.This project integrates experimental, theoretical, and computational efforts in order to answer the following fundamental questions: (1) how do key microstructural characteristics of the porous scaffold affect the critical buckling load and the distribution of local strains; (2) how do the mechanical properties of the parent collagen influence the nonlinear response of the scaffolds; (3) how does a non-homogeneous distribution of a compliant filler material affect regions and modes of elastic stability. The research plan involves experiments on additively manufactured complex 3D architectures, state-of-the-art deformation mapping at the microscale, and the development of novel multiscale models of soft architected composites that capture all aspects of the material nonlinear mechanics. The research findings and predictive tools developed will have significant impact in several areas involving soft materials ranging from biological engineering and biomimetic systems to soft robotics.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该学术与工业联络资助机会（GOALI）合作研究项目将重点研究外部载荷下软骨支架的机械性能和变形。软多孔支架通常用于促进细胞生长，用于不同组织（包括软骨和骨骼）修复和再生的治疗应用。这些支架的孔隙率有利于细胞生长和营养物质的运输。这种软植入物在植入早期阶段的机械功能主要由支架决定，支架必须承受所施加的载荷并保持其孔内细胞的完整性。软多孔材料中经常遇到的结构不稳定性既会损害支架的机械功能，也会损坏封装的细胞。研究成果将通过改造工程软骨支架来维持植入物功能、防止细胞死亡，从而提高植入手术成功的可能性，从而促进国民健康并提高数百万人的生活质量。此外，该合作项目旨在通过康奈尔大学和约翰霍普金斯大学的暑期外展项目吸引来自代表性不足的少数族裔的几名高中生和本科生。该项目整合了实验、理论和计算工作，以回答以下基本问题：（1 ）多孔支架的关键微观结构特征如何影响临界屈曲载荷和局部应变的分布； (2)母体胶原的力学性能如何影响支架的非线性响应； (3) 柔顺填充材料的非均匀分布如何影响弹性稳定性的区域和模式。该研究计划涉及增材制造的复杂 3D 结构实验、最先进的微尺度变形映射，以及开发软结构复合材料的新型多尺度模型，以捕获材料非线性力学的各个方面。所开发的研究成果和预测工具将对涉及从生物工程和仿生系统到软机器人等软材料的多个领域产生重大影响。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力优势和更广泛的评估进行评估，被认为值得支持。影响审查标准。

项目成果

A finite element implementation of finite deformation surface and bulk poroelasticity

• DOI: 10.1007/s00466-023-02398-5
• 发表时间: 2023-05
• 期刊: Computational Mechanics
• 影响因子: 4.1
• 作者: Jaemin Kim;Ida Ang;F. Ballarin;C. Hui;N. Bouklas

The Role of Buckling Instabilities in the Global and Local Mechanical Response in Porous Collagen Scaffolds

• DOI: 10.1007/s11340-022-00853-7
• 发表时间: 2022-06
• 期刊: Experimental Mechanics
• 影响因子: 2.4
• 作者: B. Kim;J. Middendorf;N. Diamantides;C. Dugopolski;S. Kennedy;E. Blahut;I. Cohen;N. Bouklas;L. Bonassar

On physics-informed data-driven isotropic and anisotropic constitutive models through probabilistic machine learning and space-filling sampling

• DOI: 10.1016/j.cma.2022.114915
• 发表时间: 2021-09
• 期刊: ArXiv
• 作者: J. Fuhg;N. Bouklas

Instabilities induced by mechanical loading determine the viability of chondrocytes grown on porous scaffolds

机械负载引起的不稳定性决定了多孔支架上生长的软骨细胞的活力

• DOI: 10.1016/j.jbiomech.2023.111591
• 发表时间: 2023
• 期刊: Journal of Biomechanics
• 影响因子: 2.4
• 作者: Kim, Byumsu;Bouklas, Nikolaos;Cohen, Itai;Bonassar, Lawrence J.
• 通讯作者: Bonassar, Lawrence J.