SBIR Phase I: Star Polymer Micelles as Targeted Drug Delivery System

SBIR 第一阶段：星形聚合物胶束作为靶向药物输送系统

• 批准号: 0230108
• 负责人: Fei Wang
• 金额: $ 10万
• 依托单位: EIC Laboratories Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-01-01 至 2003-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0230108&HistoricalAwards=false
• 关键词: SBIR; Phase; Star; Polymer; Micelles

This Small Business Innovation Research (SBIR) Phase I project will develop a novel nanostructured polymer micelle system for targeted delivery of chemotherapeutic drugs. A star structural polymer will be synthesized for use as the drug delivery vehicle. The star polymer will form unimolecular micelles under aqueous conditions. Hydrophobic drugs can be encapsulated in the unimolecular micelles and delivered to the cancer tissue via an active targeting process. Functional groups at the micelles surface will act as targeting moieties and lead the drug carrier to the desired cancer cells. The specific aims in the proposed program are to synthesize and characterize a candidate star polymer, and to conduct in vitro endothelial cell adhesive assay to determine the affinity of the star polymer to v3 and v5 integrins. Commercially, with this proposed new drug delivery system, more selective delivery by active targeting is possible. This will reduce the drug dose and undesirable side effects and make chemotherapy for cancer treatment more efficient. New drug delivery systems have had an impact on nearly every branch of medicine. Annual sales in the United States of advanced drug delivery systems exceed $10 billion alone and are rising rapidly.

这项小型企业创新研究（SBIR）I期项目将开发一种新型的纳米结构聚合物胶束系统，用于靶向化学治疗药物的靶向输送。恒星结构聚合物将合成作为药物递送车。 恒星聚合物将在水性条件下形成单分子胶束。疏水性药物可以封装在单分子胶束中，并通过主动靶向过程传递到癌组织。胶束表面的官能团将充当靶向部分，并将药物载体带到所需的癌细胞。拟议程序中的具体目的是合成和表征候选星聚合物，并进行体外内皮细胞粘合剂测定，以确定星形聚合物与V3和V5整合蛋白的亲和力。在商业上，借助此拟议的新药物输送系统，可以通过主动靶向进行更有选择的递送。这将减少药物剂量和不良副作用，并使癌症治疗的化学疗法更有效。新药输送系统几乎对医学的每个分支都有影响。美国高级药物输送系统的年销售额仅超过100亿美元，并且正在迅速上升。