COBRE for Stress, Trauma and Resilience (STAR)

COBRE 压力、创伤和复原力 (STAR)

基本信息

批准号：
10686037
负责人：
LAURA R STROUD
金额：
$ 220.37万
依托单位：
MIRIAM HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-15 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10686037
关键词：
Address Adult Adverse event Affective American Behavioral Behavioral Mechanisms Biological Biological Markers Cardiovascular Diseases Centers of Research Excellence Child Child Abuse and Neglect Child Sexual Abuse Childhood Chronic Obstructive Pulmonary Disease Communities Data Development Diet Dimensions Disease Doctor of Philosophy Documentation Education Ethics Evaluation Exposure to Faculty Faculty Recruitment Funding Goals Health Hospitals Hypertension Inflammatory Infrastructure Intervention Laboratories Lead Leadership Life Cycle Stages Link Longevity Measurement Measures Mental Depression Mental Health Mental disorders Mentors Mentorship Metabolic Methods Minority Groups Obesity Outcome Phase Pilot Projects Population Heterogeneity Poverty Pregnancy Recording of previous events Reporting Research Research Personnel Research Project Grants Research Support Resources Rhode Island Risk Sampling Science Scientist Strategic Planning Stress Symptoms Teacher Professional Development Technology Time Training Trauma Trauma Research Underrepresented Minority United States National Institutes of Health Vulnerable Populations Weight Gain adverse childhood events career childhood adversity community partnership data management deprivation early childhood early life adversity early-career faculty emotion regulation ethnic minority executive function experience experimental study faculty mentor food insecurity human subject improved in vivo innovation maltreatment multidisciplinary neglect next generation novel pediatric trauma perinatal outcomes physical conditioning poor health outcome pregnancy disorder programs racial minority recruit resilience resilience research statistics stress reactivity stressor substance use young adult

项目摘要

PROJECT SUMMARY / ABSTRACT There is increasing evidence for a profound and persistent impact of childhood stress and trauma on psychological and physical health outcomes over the lifespan. The strength and consistency of these associations has led to a paradigm shift in approaching adult disease in which addressing the early childhood origins of health and disease is considered to be equal to if not more critical than intervention efforts with adults. However, despite the magnitude of risk associated with adverse childhood experiences, there is limited understanding of the precise mechanisms by which early adversity impacts health. We propose to establish a Phase I Center of Biomedical Research Excellence (COBRE) for Stress, Trauma, and Resilience (STAR) at The Miriam Hospital to address this critical gap. The STAR COBRE is unified by a conceptual framework focused on (a) isolating/disentangling specific stress exposures and traumas, and (b) identifying proximal mechanisms of risk and resilience with in-vivo ecological sampling that will lead rapidly to novel and actionable intervention targets to improve health. The COBRE incorporates a life course approach, with an emphasis on sensitive periods of development—pregnancy, childhood, and young adulthood. Three promising, early career Project Leaders, a junior faculty recruit with expertise in STAR from an under-represented minority group, and a diversity-focused pilot project program funded by The Miriam Hospital form the nexus of the STAR CO- BRE. Co-mentorship by two leading NIH-funded scientists with complementary expertise will catalyze the transition of the Project Leaders to independent funding. Dr. Bublitz will utilize cutting-edge ecological methods to understand links between maternal history of childhood sexual abuse and hypertensive disorders of pregnancy. Dr. Evans will conduct a naturalistic experiment in children to elucidate the specific impact of food insecurity from other poverty-related stressors on diet, inflammatory and metabolic biomarkers and summer weight gain; Dr. Vergara-Lopez will utilize a novel dimensional approach to childhood maltreatment to contrast the impact of deprivation (neglect) vs. threat (abuse) on young adult emotion regulation strategies and mental health symptoms. To support Project Leaders and the STAR COBRE, we will establish an Administrative Core, including a community advisory board and a state-of-the art Mentoring and Education program, and two research cores: the Technology, Assessment, Data, and Analysis (TADA) Core will support methods harnessing cutting-edge technology, data management and statistics; the Human Subjects and Vulnerable Populations (VP) Core will support recruitment/retention of vulnerable and diverse populations and community partnerships. The STAR COBRE will serve as the only research center in Rhode Island focused on stress, trauma, and resilience. Our long-term goal is to develop and sustain a critical mass of investigators to establish The Miriam Hospital as a vibrant regional and national hub for transformative research into mechanisms of risk and resilience following childhood exposure to stress, trauma, and adversity.

项目摘要 /摘要越来越多的证据表明，童年时期的压力和创伤对整个生命周期中的心理和身体健康成果产生了深远而持久的影响。这些关联的力量和一致性导致接近成人疾病的范式转移，以解决健康的早期起源和疾病被认为与与成年人的干预工作相比，疾病等于同样重要的话。但是，尽管与不利的童年经历相关的风险大小，但对早期广告影响健康的确切机制。我们建议建立I期中心 Miriam的压力，创伤和弹性（星星）的生物医学研究卓越（COBRE）医院解决这个关键差距。恒星毛绒是由一个概念框架统一的（a）隔离/解开特定的应力暴露和创伤，以及（b）确定的近端机制风险和韧性通过体内生态取样，这将迅速导致新颖且可操作的干预目标以改善健康。鞋底结合了生命课程的方法，重点是敏感的发展时期 - 怀孕，童年和成年期。三个诺言，早期职业项目领导者，一名初级教师招聘，在一个代表性不足的少数民族团体中拥有专业知识，以及由Miriam医院资助的以多样性为中心的飞行员项目计划，由Star共同的联系布雷。两名由NIH资助的科学家拥有完整专业知识的委员会将促进项目领导者向独立资金的过渡。 Bublitz博士将利用尖端的生态方法了解儿童期性虐待病史与怀孕的高血压疾病之间的联系。埃文斯博士将对儿童进行自然主义实验，以阐明其他与贫困相关的压力源对饮食，炎症和代谢生物标志物以及夏季的粮食不安全感的特定影响体重增加； Vergara-Lopez博士将利用一种新颖的维度方法来对比剥夺（忽视）与威胁（滥用）对年轻成人情绪调节策略和精神的影响健康症状。为了支持项目负责人和星际鞋带，我们将建立一个行政核心，包括社区顾问委员会和最先进的指导和教育计划，两个研究核心：技术，评估，数据和分析（TADA）核心将支持利用尖端技术，数据管理和统计数据的方法；人类受试者和弱势群体（VP）核心将支持弱势和潜水人群和社区的招募/保留伙伴关系。这颗星形杂货店将成为罗德岛州唯一的研究中心压力，创伤和韧性。我们的长期目标是发展和维持大量的调查人员将米里亚姆医院建立为充满活力的区域和国家枢纽，用于在儿童期暴露于压力，创伤和广告后的风险和韧性机制中进行变革性研究。

项目成果

期刊论文数量（22）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Dynamics of Amino Acid Metabolism, Gene Expression, and Circulomics in a Recombinant Chinese Hamster Ovary Cell Line Adapted to Moderate and High Levels of Extracellular Lactate.

DOI：
10.3390/genes14081576
发表时间：
2023-08-02
期刊：
GENES
影响因子：
3.5
作者：
Chitwood, Dylan G.;Uy, Lisa;Fu, Wanfang;Klaubert, Stephanie R.;Harcum, Sarah W.;Saski, Christopher A.
通讯作者：
Saski, Christopher A.

Tsc2 coordinates neuroprogenitor differentiation.

DOI：
10.1016/j.isci.2023.108442
发表时间：
2023-12-15
期刊：
ISCIENCE
影响因子：
5.8
作者：
Riley, Victoria A.;Shankar, Vijay;Holmberg, Jennie C.;Sokolov, Aidan M.;Neckles, Victoria N.;Williams, Kaitlyn;Lyman, Rachel;Mackay, Trudy F. C.;Feliciano, David M.
通讯作者：
Feliciano, David M.

Premium and Non-Premium Cigar Use Among a Nationally Representative Sample of Reproductive Age Women: Findings from the 2010-2019 National Survey on Drug Use and Health.

DOI：
10.1093/ntr/ntad020
发表时间：
2023-07-28
期刊：
NICOTINE & TOBACCO RESEARCH
影响因子：
4.7
作者：
Sharma, Eva;Gautam, Prem;Jao, Nancy C.;Stroud, Laura R.
通讯作者：
Stroud, Laura R.

Exploring the Impact of Maternal and Paternal Acceptance on Adolescent Girls' Emotion Regulation.

探索母亲和父亲的接受度对青春期女孩情绪调节的影响。

DOI：
10.1007/s10578-022-01405-9
发表时间：
2024
期刊：
Child psychiatry and human development
影响因子：
2.9
作者：
Vergara-Lopez,Chrystal;Sokol,NatashaA;Bublitz,MargaretH;Gaffey,AllisonE;Gomez,Andrea;Mercado,Nadia;Silk,JenniferS;Stroud,LauraR
通讯作者：
Stroud,LauraR

Psychological Risk Factors in Pulmonary Rehabilitation: ANXIETY, DEPRESSION, SOCIAL ISOLATION, AND COGNITIVE IMPAIRMENT.

肺康复中的心理危险因素：焦虑、抑郁、社会孤立和认知障碍。