Neural Mechanisms of Dominance Behavior

支配行为的神经机制

• 批准号: 9726819
• 负责人: Donald Edwards
• 金额: $ 29.68万
• 依托单位: Georgia State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-04-01 至 2002-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9726819&HistoricalAwards=false
• 关键词: Neural; Mechanisms; Dominance; Behavior

Social relationships among animals influence their behavior, and do so by affecting the neural circuits and responses that control behavior. A primary link between social status and behavior occurs through the release of neuromodulators that have both widespread and targeted effects within the nervous system. One neuromodulator, serotonin, has been implicated in the expression of social ordering behaviors in a wide range of vertebrates and invertebrates, including primates, rodents, fish and crustaceans. The neural mechanisms that link serotonin's effects to the expression of dominance status have been studied most thoroughly in crustaceans, particularly lobsters and crayfish. During the current grant period the social dominance status of a crayfish was found to predict the effect of the neuromodulator serotonin on the neural circuit for the taiflip behavior. Serotonin enhances the response of the Lateral Giant (LG) tailflip command neuron to its normal mechanosensory input in isolated crayfish and in socially dominant crayfish, and inhibits the cell in subordinate animals. The differences result from corresponding differences in the population of serotonin receptors. The present proposal continues this research by determining the sources of serotonin that modulate LG in freely behaving animals, and by asking where and how serotonin has its different effects on LG in the animals of different social status. Blood levels of serotonin in freely behaving crayfish will be measured during fights, and the responses of LG to serotonin, serotonin agonists and antagonists will be measured with standard electrophysiological techniques.

动物之间的社会关系会影响其行为，并通过影响控制行为的神经回路和反应来做到这一点。 社会地位和行为之间的主要联系是通过释放神经系统中具有广泛且有针对性影响的神经调节剂发生的。 一种神经调节剂5-羟色胺与在各种脊椎动物和无脊椎动物中的社会顺序行为的表达有关，包括灵长类动物，啮齿动物，鱼类和甲壳类动物。 在甲壳类动物（尤其是龙虾和小龙虾）中，最彻底地研究了5-羟色胺作用与优势状态表达的神经机制。 在当前赠款期间，发现小龙虾的社会优势状态可以预测神经调节剂5-羟色胺对神经回路对taiflip行为的影响。 5-羟色胺增强了侧向巨型（LG）尾flip命令神经元对其在孤立的小龙虾和社会主导的小龙虾中的正常机械感觉输入的反应，并抑制下属动物中的细胞。差异是由于5-羟色胺受体群体的相应差异引起的。 本提案通过确定调节自由表现的动物LG的血清素的来源，并询问5-羟色胺在不同的社会地位动物中对LG的影响不同，从而继续这项研究。 在战斗过程中将测量5-羟色胺的血液水平，LG对5-羟色胺，5-羟色胺激动剂和拮抗剂的反应将通过标准的电生理技术测量。