Neural Mechanisms of Dominance Behavior

支配行为的神经机制

• 批准号: 9423846
• 负责人: Donald Edwards
• 金额: $ 26.46万
• 依托单位: Georgia State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-04-01 至 1998-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9423846&HistoricalAwards=false
• 关键词: Neural; Mechanisms; Dominance; Behavior

9423846 Edwards The relationship between the brain and behavior is a dynamic two-way interaction. Biologists would like to understand both how the brain generates behaviors, and also how behavioral contexts produce effects on the brain. It is well-known that social behaviors produce effects on the brain (and therefore other behaviors), but the mechanisms for such interactions is largely unknown. In this grant Dr. Edwards and his colleagues will examine how the dominance status of animals impacts the chemistry of the nervous system and the subsequent expression of well-defined behaviors such as escape. The brain chemical serotonin can modify escape behavior. Dr. Edwards group has evidence that serotonin's effects on brain cells mediating escape vary in fundamentally different ways in dominant animals versus subordinate animals. The mechanisms for serotonin's differential effects will be analyzed at the level of identified cells and specific subtypes of the serotonin receptor. This work will provide new inqights into the pathways by which social behavior and brain function interact. ***

9423846爱德华兹大脑与行为之间的关系是动态的双向相互作用。 生物学家想了解大脑如何产生行为，以及行为环境如何对大脑产生影响。 众所周知，社会行为会对大脑（以及其他行为）产生影响，但是这种相互作用的机制在很大程度上是未知的。 在这笔赠款中，爱德华兹博士及其同事将研究动物的优势状况如何影响神经系统的化学反应以及随后的表达明确定义的行为，例如逃生。 大脑化学5-羟色胺可以改变逃生行为。 爱德华兹（Edwards Group）博士有证据表明，5-羟色胺对介导的脑细胞的影响在主导动物与下属动物的根本不同方式不同。 将在鉴定细胞的水平和5-羟色胺受体的特定亚型上分析5-羟色胺差异作用的机制。 这项工作将为社会行为和大脑功能相互作用的途径提供新的核心。 ***