Multidisciplinary Collaborative Research: Amines and Agonistic Behavior in Crustaceans

多学科合作研究：甲壳类动物的胺和竞争行为

基本信息

批准号：
9616198
负责人：
Donald Edwards
金额：
$ 7.5万
依托单位：
Georgia State University
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
1996
资助国家：
美国
起止时间：
1996-09-01 至 1999-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=9616198&HistoricalAwards=false
关键词：
Multidisciplinary Collaborative Research Amines Agonistic

Multidisciplinary Collaborative Research Amines Agonistic

项目摘要

Some biochemicals in the brain apparently affect behavior; for example, a high level of the amine compound serotonin has been linked to aggression in a wide range of both vertebrate and invertebrate species. It is very difficult in the complex brain of vertebrate animals to study the way in which particular chemicals affect the function of particular single nerve cells, or neurons. In contrast, some invertebrate animals have limited numbers of large identifiable neurons, allowing analysis of complex behavioral processes at the level of the precise cells thought to be involved. This collaborative work in three different laboratories exploits the well-studied behavior of crayfish and the very accessible nervous system of these animals, as a model system. A variety of behavioral, pharmacological, molecular and physiological approaches are used to determine how amine compounds modulate the aggressive activity of dominant and non-dominant animals in their social hierarchies, and how particular amine- containing nerve cells are important in these behaviors. Results from this work will be fundamental to understanding how compounds that are used by certain cells as neural transmitters also can have effects on modulating behavior. By clarifying the roles of amines in complex behavioral processes, such as aggression in the nervous systems of animals far more complex than this model system, the results will have an impact beyond cellular neuroscience and neuroethology to other areas of behavior neuroscience and psychology.

大脑中的一些生化物显然会影响行为。例如，高水平的胺化合物5-羟色胺与脊椎动物和无脊椎动物种类的侵略有关。在脊椎动物的复杂大脑中，很难研究特定化学物质影响特定单神经细胞或神经元功能的方式。相比之下，一些无脊椎动物的动物具有有限的大量可识别神经元，可以分析在被认为涉及的精确细胞水平上的复杂行为过程。这项在三个不同实验室的合作工作利用了小龙虾的精心研究行为以及这些动物的神经系统非常容易成为模型系统。多种行为，药理，分子和生理方法用于确定胺在其社会等级中如何调节主要和非主要动物的侵略活性，以及特定含有胺的神经细胞在这些行为中如何重要。这项工作的结果将是了解某些细胞用作神经发射器的化合物如何也会对调节行为产生影响的基础。通过阐明胺在复杂的行为过程中的作用，例如在动物的神经系统中的侵略性比该模型系统更为复杂，结果将对其他行为神经科学和心理学领域的其他领域产生影响。