Synthetic and Mechanistic Studies on the Homogeneous Catalysis of Transition Metal Complexes

过渡金属配合物的均相催化合成及机理研究

• 批准号: 9103765
• 负责人: Iwao Ojima
• 金额: $ 19.28万
• 依托单位: SUNY at Stony Brook
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-08-01 至 1994-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9103765&HistoricalAwards=false
• 关键词: Synthetic; Mechanistic; Studies; Homogeneous; Catalysis

The project focuses on three major efforts. First, a mechanistic study on Co-Rh mixed metal catalyst systems will be carried out to probe catalysis by Co-Rh bimetallic di- and tetranuclear complexes with regard to the highly regio- and stereoselective silylformylation and hydrosilylation of 1-alkynes. Second, applications of the silylformylation reaction to the silylformylation-annulation of alkynyl amines and silylformylation-carbocyclization will be examined as a route to functionalized heterocycles. Third, approaches to effective asymmetric induction will be studied by the use of chelation-directed regio- and stereocontrol in carbonylations. %%% With this award the Synthetic Organic Program renews support of the research of Dr. Iwao Ojima of the Department of Chemistry at the State University of New York, Stonybrook. The ultimate goal of the work is to design and develop multi-functional multi-catalyst systems that will enable the chemist to carry out multi-step synthesis in one reaction vessel in a highly organized manner. The research wiil provide new and efficient synthetic methods, and an improved understanding of both bimetallic catalysis and regio- and stereocontrol mediated by transition metal complexes.

该项目重点开展三项工作。 首先，将进行Co-Rh混合金属催化剂体系的机理研究，以探讨Co-Rh双金属双核和四核配合物对1-炔烃的高度区域和立体选择性甲酰化和氢化硅烷化的催化作用。 其次，将研究甲硅烷基甲酰化反应在炔基胺的甲硅烷基甲酰化-环化和甲硅烷基甲酰化-碳环化中的应用，作为官能化杂环的途径。 第三，将通过在羰基化中使用螯合导向的区域和立体控制来研究有效的不对称诱导的方法。 %%% 凭借这一奖项，合成有机项目再次支持纽约州立大学石溪分校化学系 Iwao Ojima 博士的研究。 这项工作的最终目标是设计和开发多功能多催化剂系统，使化学家能够以高度组织的方式在一个反应​​容器中进行多步合成。 该研究将提供新的、有效的合成方法，并加深对双金属催化以及过渡金属配合物介导的区域和立体控制的理解。