Synthetic and Mechanistic Studies on the Homogeneous Catalysis of Transition Metal Complexes

过渡金属配合物的均相催化合成及机理研究

• 批准号: 9103765
• 负责人: Iwao Ojima
• 金额: $ 19.28万
• 依托单位: SUNY at Stony Brook
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-08-01 至 1994-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9103765&HistoricalAwards=false
• 关键词: Synthetic; Mechanistic; Studies; Homogeneous; Catalysis

The project focuses on three major efforts. First, a mechanistic study on Co-Rh mixed metal catalyst systems will be carried out to probe catalysis by Co-Rh bimetallic di- and tetranuclear complexes with regard to the highly regio- and stereoselective silylformylation and hydrosilylation of 1-alkynes. Second, applications of the silylformylation reaction to the silylformylation-annulation of alkynyl amines and silylformylation-carbocyclization will be examined as a route to functionalized heterocycles. Third, approaches to effective asymmetric induction will be studied by the use of chelation-directed regio- and stereocontrol in carbonylations. %%% With this award the Synthetic Organic Program renews support of the research of Dr. Iwao Ojima of the Department of Chemistry at the State University of New York, Stonybrook. The ultimate goal of the work is to design and develop multi-functional multi-catalyst systems that will enable the chemist to carry out multi-step synthesis in one reaction vessel in a highly organized manner. The research wiil provide new and efficient synthetic methods, and an improved understanding of both bimetallic catalysis and regio- and stereocontrol mediated by transition metal complexes.

该项目着重于三项主要努力。 首先，将对Co-RH双金属Di-和四核复合物进行一项关于Co-RH混合金属催化剂系统的机理研究，以探测高度的区域性和立体选择性的Silylformylation和1-烷烃的水硅烷化。 其次，将辅助性甲硅烷基化反应对烷基胺和甲硅烷基化 - carbocyclization的甲硅烷基形式化的应用，将被检查为实现功能化杂环的途径。 第三，通过在羰基化中使用螯合定向的区域和立体控制，将研究有效的不对称诱导方法。 %% %%通过该奖项的合成有机计划更新了纽约州立大学化学系的Iwao Ojima博士的研究，Stonybrook。 这项工作的最终目标是设计和开发多功能的多催化剂系统，该系统将使化学家能够以高度组织的方式在一个反应​​容器中进行多步综合。 这项研究提供了新的有效的合成方法，以及对双金属催化以及通过过渡金属复合物介导的区域和立体控制的提高理解。