New Methods in Catalytic Organic Synthesis with Transition Metal Complexes

过渡金属配合物催化有机合成新方法

• 批准号: 0809315
• 负责人: Iwao Ojima
• 金额: $ 44.1万
• 依托单位: SUNY at Stony Brook
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0809315&HistoricalAwards=false
• 关键词: New; Methods; Catalytic; Organic; Synthesis

This project will continue and expand the ongoing investigation on new and efficient higher order cycloaddition and cyclohydrocabonylation reactions. These reactions allow for constructing multiple bonds all at once and for converting linear starting materials to polycyclic compounds in one step. In addition, the fine-tunable phosphorus ligands developed successfully in the last funding period will be applied to the development of highly efficient catalytic asymmetric reactions that are useful for the synthesis of enantiomerically pure compounds. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Iwao Ojima of the Department of Chemistry at the State University of New York at Stony Brook. Professor Ojima's research efforts revolve around the discovery of highly efficient catalytic methodology for the rapid construction of polycyclic and enantiomerically pure compounds. These compounds are of significant biological and medicinal importance. In addition, the proposed chemistry is green in nature, as it has high selectivity and generates little waste materials.

该项目将继续并扩大正在进行的新型高效高阶环加成和环氢羰基化反应的研究。 这些反应允许一次构建多个键，并一步将直链起始材料转化为多环化合物。 此外，上一资助期成功开发的微调磷配体将应用于高效催化不对称反应的开发，这些反应可用于合成对映体纯的化合物。有机与高分子化学项目通过该奖项支持纽约州立大学石溪分校化学系 Iwao Ojima 教授的研究。 Ojima 教授的研究工作围绕着发现快速构建多环和对映体纯化合物的高效催化方法。 这些化合物具有重要的生物学和医学重要性。 此外，所提出的化学方法本质上是绿色的，因为它具有高选择性并且产生很少的废料。