早期类风湿性关节炎的滑膜炎发病机制的影像学研究

Rheumatoid arthritis (RA) is a chronic autoimmune disease, morbidity of up to 50% in suffering two years. Studies suggest that early RA exist clinical therapeutic window. Within this time window, the treatment effect is remarkable, even to terminate the disease process. Imaging examination is important for the early diagnosis of RA, but it may take an average of 2.5 years from the RA onset to being confirmed. It is a scientific problem to be non-invasively solved by imaging diagnosis of the early RA...This study is to investigative the synovitis in early RA animal models mainly by μMRI. The contents of this study include the imaging of immunological pathogenesis of synovitis by molecular imaging of sFas, IL-17, TNF-a, FLS and MMPs; imaging of Synovial microscopic pathological changes by the microvascular density, inflammatory cells arrangement, biochemical characteristics of synovial membrane matrix. The aim of this study is to demonstrate the imaging characteristics of the key pathogenesis in early RA, to make non-invasive in vivo imaging diagnosis of early RA, and to provide effective techniques for imaging diagnosis of early RA. It will provide reliable basis for early treatments, clinical observation and following-up, and prevention or decrease of disability.

RA是一种慢性自身免疫性关节疾病，两年致残率高达50%。研究证明，RA发病初期存在有临床治疗窗，该时间窗内治疗效果显著，甚至能终止疾病进程。影像学检查对RA的早期诊断至关重要，但目前RA从发病到确诊平均需要2.5年。如何尽早无创性地发现RA, 是当前影像诊断学亟待解决的科学问题。. 本研究致力于通过影像学方法，在早期RA的动物模型，进行关节滑膜的以μMRI为主的影像学研究。内容包括滑膜炎免疫学发病机制成像：sFas、IL-17、TNF-a、MMPs 等分子成像和FLS的细胞成像；滑膜显微病理改变特征成像：微血管密度、炎性细胞排列结构、滑膜基质生化成分等的成像，明确早期RA的关键性发病机制和病理改变的影像学表现特征，实现活体无创性早期RA的影像诊断，为建立一套早期 RA 的影像学诊断方法提供有效技术途径。为临床早期治疗、疗效观察及追踪、防止或减少残疾发生提供可靠依据。