人格障碍中噩梦经历与其负性情绪脑区加工特点的关联

The exact etiopathology of the personality disorders is unclear, and its pharmacotherapy remains almost non-effective. Patients often have fluctuated emotions, nightmare experience, and altered recognition of negative emotions and control of suicidal behaviors. However, it remains unclear which cerebral areas are responsible for processing the negative emotions in personality disorder patients with frequent nightmare experience. We have hypothesized that, during conscious state, these patients display quicker and stronger responses to negative emotions, their related cerebral areas are more activated, and these abnormalities are correlated with their personality traits, emotional states and nightmare experience observed in clinics. Therefore, we will invite personality disorder patients with frequent (n = 75) and less/ no (n = 75) nightmare experience, and healthy volunteers (n = 150), during conscious state, to undergo ERPs and fMRI tests under different emotional exposures (fear, disgust and sadness VS. happiness, erotica and neutral), and to undergo questionnaires measuring personality trait, depression state, nightmare experience and life event, in order to look for the characteristics of the responsible cerebral areas and their relationships with the clinical symptoms. The related results would help to explain the mechanisms behind the cognition and control of negative emotions in these patients, and to offer support to the cognitive-behavioral therapy applying to them.

人格障碍确切病因不明且药物治疗基本无效，患者常有情绪波动、噩梦经历，对负性情绪的识别及自杀行为控制上也存在异常。而噩梦多发人格障碍患者在加工负性情绪的脑区有何特点尚且不知。我们假设这类患者在清醒时对负性情绪加工更快、反应更强烈、相关脑区激活更多，且与其人格特质、情绪状态和噩梦经历相关。因此我们打算在噩梦多发人格障碍 (n = 75)、噩梦少发/不发人格障碍 (n = 75) 患者及正常志愿者 (n = 150) 中进行情绪情景 (恐惧、厌恶和悲伤 VS. 快乐、色情、平静) 下的ERPs和fMRI检测，同时测评其人格特质、抑郁状态、噩梦经历和生活事件，以期找到噩梦多发人格障碍患者在清醒状态下加工负性情绪的脑区特点及其与临床症状的关联。相关结果可以帮助理解人格障碍的负性情绪认知与控制，也可以为对其实施认知-行为治疗提供支持。

人格障碍确切病因不明且药物治疗基本无效，患者常有情绪波动、噩梦经历，对负性情绪的识别及自杀行为控制上也存在异常。而噩梦多发人格障碍患者在加工负性情绪的脑区有何特点尚且不知。我们假设这类患者在清醒时对负性情绪加工更快、反应更强烈、相关脑区激活更多，且与其人格特质、情绪状态和噩梦经历相关。因此我们对噩梦多发人格障碍、噩梦少发/不发人格障碍患者及正常志愿者中进行人格特质、抑郁状态、噩梦经历和生活事件的测评，同时请他们在情绪情景 (恐惧、厌恶、悲伤 VS. 快乐、色情、平静) 下进行ERPs和fMRI检测，结果发现障碍人格类型可被正常人格特质预测，噩梦多发患者相对于健康志愿者有着更高的抑郁倾向且在大多数障碍人格特质上得分更高，通过ERPs和fMRI测试也发现了噩梦多发患者在情绪加工和调控时脑功能存在异常。相关结果可以帮助理解人格障碍/ 噩梦多发的情绪认知与控制，也可以为对其实施认知-行为治疗提供支持。

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