Development of pH-responsive carriers for the controlled release of encapsulated acidifying and antibacterial agents

开发用于控制释放封装酸化剂和抗菌剂的 pH 响应载体

• 批准号: 531450-2018
• 负责人: Mauzeroll, JanineJ
• 金额: $ 4.07万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=747530
• 关键词: Development; pH; responsive; carriers; controlled

With the ever-present specter of drug-resistant microbes and emerging infectious diseases looming large,establishing and maintaining stringent and up-to-date disinfection practices has taken on paramount importancein a growing number of industries. In addition to effectively neutralizing pathogens, novel disinfectantformulations must be, as much as possible, environmentally benign and nontoxic to individuals handling thesesubstances. In the sanitation field, chlorine has long found application as a straightforward broad-spectrumdisinfectant. However, certain microbes including Cryptosporidium - the most prevalent causative agent inrecreational water illnesses - are resistant to chlorine treatment. Addressing this issue requires either thedevelopment of novel disinfectants or refinement of the efficiency of existing approaches. To this end, wepropose to develop disinfectant formulations based on pH-sensitive liposomes. Liposomes (lipid bilayervesicles) are sustainable, inherently biocompatible structures that have found broad application in the deliveryof encapsulated compounds, including significantly increased efficiency in the delivery of antimicrobials tobacteria. Our system will comprise liposomes encapsulating quaternary ammonium and peracetic aciddisinfectants that will undergo destabilization and fusion with microbial cells following a change in pH. Withthe ability to be applied in the bulk solution or as a surface treatment, this novel disinfectant delivery systemwill represent a significant step forward in aligning disinfectant practices in the sanitation industry withcontemporary challenges.

随着耐药微生物的幽灵和新出现的传染病的日益严重，建立和维持严格且最新的消毒实践在越来越多的行业中变得至关重要。除了有效中和病原体之外，新型消毒剂配方还必须尽可能对环境无害，并且对处理这些物质的个人无毒。在卫生领域，氯长期以来作为一种简单的广谱消毒剂得到应用。然而，某些微生物，包括隐孢子虫（娱乐用水疾病中最常见的病原体），对氯处理具有抵抗力。解决这个问题需要开发新型消毒剂或提高现有方法的效率。为此，我们建议开发基于pH敏感脂质体的消毒剂配方。脂质体（脂质双层囊泡）是可持续的、固有的生物相容性结构，在封装化合物的递送中具有广泛的应用，包括显着提高抗菌剂向细菌的递送效率。我们的系统将包含封装季铵和过乙酸消毒剂的脂质体，这些消毒剂会在 pH 值变化后发生不稳定并与微生物细胞融合。这种新型消毒剂输送系统能够应用于散装溶液或作为表面处理剂，将代表着卫生行业消毒剂实践与当代挑战相一致的重要一步。