Development of pH-responsive carriers for the controlled release of encapsulated acidifying and antibacterial agents.

开发用于控制释放封装酸化剂和抗菌剂的 pH 响应载体。

• 批准号: 531450-2018
• 负责人: Mauzeroll, Janine
• 金额: $ 4.07万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=698061
• 关键词: Development; pH; responsive; carriers; controlled

With the ever-present specter of drug-resistant microbes and emerging infectious diseases looming large, establishing and maintaining stringent and up-to-date disinfection practices has taken on paramount importance in a growing number of industries. In addition to effectively neutralizing pathogens, novel disinfectant formulations must be, as much as possible, environmentally benign and nontoxic to individuals handling these substances. In the sanitation field, chlorine has long found application as a straightforward broad-spectrum disinfectant. However, certain microbes including Cryptosporidium - the most prevalent causative agent in recreational water illnesses - are resistant to chlorine treatment. Addressing this issue requires either the development of novel disinfectants or refinement of the efficiency of existing approaches. To this end, we propose to develop disinfectant formulations based on pH-sensitive liposomes. Liposomes (lipid bilayer vesicles) are sustainable, inherently biocompatible structures that have found broad application in the delivery of encapsulated compounds, including significantly increased efficiency in the delivery of antimicrobials to bacteria. Our system will comprise liposomes encapsulating quaternary ammonium and peracetic acid disinfectants that will undergo destabilization and fusion with microbial cells following a change in pH. With the ability to be applied in the bulk solution or as a surface treatment, this novel disinfectant delivery system will represent a significant step forward in aligning disinfectant practices in the sanitation industry with contemporary challenges.

随着耐药微生物的幽灵和新出现的传染病的不断出现， 建立和维持严格且最新的消毒措施已变得至关重要 在越来越多的行业中。新型消毒剂除了能有效中和病原体外 制剂必须尽可能对环境无害且对处理这些物质的人员无毒 物质。在卫生领域，氯长期以来作为一种简单的广谱剂得到应用 消毒剂。然而，某些微生物，包括隐孢子虫——最常见的病原体 娱乐用水疾病 - 对氯处理有抵抗力。解决这个问题需要 开发新型消毒剂或改进现有方法的效率。为此，我们 建议开发基于pH敏感脂质体的消毒剂制剂。脂质体（脂质双层 囊泡）是可持续的、本质上具有生物相容性的结构，在递送中得到了广泛的应用 封装的化合物，包括显着提高抗菌药物的输送效率 细菌。我们的系统将包含封装季铵和过乙酸的脂质体 pH 值变化后会发生不稳定并与微生物细胞融合的消毒剂。和 这种新型消毒剂输送系统能够应用于散装溶液或作为表面处理剂 将代表卫生行业消毒剂实践与 当代的挑战。