Design, Synthesis and Evaluation of Functional Benzosiloles and New Reactions of Strained Carbocycles

功能性苯并硅杂环化合物和应变碳环新反应的设计、合成和评价

• 批准号: RGPIN-2021-03925
• 负责人: Pagenkopf, Brian
• 金额: $ 1.75万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=748038
• 关键词: Design; Synthesis; Evaluation; Functional; Benzosiloles

We are a synthetic organic chemistry laboratory and are internationally recognized experts in the art of manipulating carbon-containing molecules. We develop new chemical reactions and strategically transform molecules with certain characteristics into new molecules with different properties. 1. Synthesis of Novel Benzosilole Chromophores. Fluorescent chromophores are molecules that glow or give off light when irradiated with invisible ultraviolet (or "black") light. They are critical for many technologies in everyday life, including electronics, medical diagnostics, and even laundry detergents that bring extra whiteness to T-shirts. We use advanced organic chemistry to prepare novel benzosilole chromophores that contain silicon atoms with exciting new properties for commercial applications. Our experience with investigating structure-activity relationships (SARs) of drugs influences our synthetic planning in the systematic optimization of chromophores. 2. Reactions of Strained Donor-acceptor Carbocyles. A carbon atom is generally in one of three configurations when bonded. We make small rings with just three or four carbon atoms, in which the distorted bond angle increases strain and facilitates ring opening, and we then intercept the breakage with complementary molecules to create new chemical entities. We combine molecules in novel ways and reveal new synthetic methods, which are the cornerstone of drug discovery, pharmaceuticals, and specialty chemicals. EDI and HQP Training. My carefully crafted HQP training strategy revolves around the framework of synthetic organic chemistry. All HQP are expected to respect a fair and inclusive work environment, participate in activities that foster professional growth, and fully support the learning and engagement of others within the group and in the broader community. My HQP acquire technical skills in synthetic chemistry and translational skills in: writing, data and time management, teamwork, public speaking, etc. The advanced chemistry skills that I foster in my HQP build upon understanding the broadest aspects of synthetic organic chemistry, which not only make them particularly desired by employers in pharmaceutical and related chemical manufacturing industries, but also provide them with a valuable transferable skill set in the age of silo education. My HQP have published important research results, earned awards and scholarships, and secured positions in academia, research labs, and pharmaceutical industries. Impact. The research produced by my diverse group of HQP benefits society in the long term by helping develop new chemical entities and processes, and these contributions will make medications more easily accessible and more economical to manufacture. We are also at the forefront of creating novel materials to open doors to and pave the way for projected high-tech applications towards a green economy.

我们是一家合成有机化学实验室，是操纵含碳分子的艺术方面的国际公认专家。我们开发新的化学反应，并从策略上转化具有某些特征的分子转化为具有不同特性的新分子。 1。新型苯并硅发色团的合成。荧光发色团是当用无形的紫外线（或“黑色”）光照射时发光或散发光的分子。它们对于日常生活中的许多技术至关重要，包括电子，医学诊断，甚至是洗衣粉为T恤带来额外的白度。我们使用先进的有机化学来制备新型的苯并硅硅色生色团，其中包含具有令人兴奋的新特性用于商业应用的硅原子。我们研究药物的结构活性关系（SARS）的经验影响了我们在发色团系统优化的合成计划。 2。紧张的供体碳纤维的反应。键合时，碳原子通常在三个构型中之一。我们只用三个或四个碳原子制作小环，其中扭曲的键角会增加应变并促进环开口，然后我们用互补的分子拦截破裂以创建新的化学实体。我们以新颖的方式结合了分子，并揭示了新的合成方法，这些方法是药物发现，药物和特种化学物质的基石。 EDI和HQP培训。我精心制作的HQP培训策略围绕合成有机化学的框架。预计所有HQP将尊重公平和包容的工作环境，参与促进专业成长的活动，并充分支持小组内和更广泛社区中他人的学习和参与。 My HQP acquire technical skills in synthetic chemistry and translational skills in: writing, data and time management, teamwork, public speaking, etc. The advanced chemistry skills that I foster in my HQP build upon understanding the broadest aspects of synthetic organic chemistry, which not only make them particularly desired by employers in pharmaceutical and related chemical manufacturing industries, but also provide them with a valuable transferable skill set in the age of silo education.我的HQP已发表了重要的研究成果，获得了奖项和奖学金，并确保了学术界，研究实验室和制药行业的职位。影响。从长远来看，我多样化的HQP群体通过帮助开发新的化学实体和流程来使社会的研究受益，这些贡献将使药物更容易获得，更经济地制造。我们也处于创建新颖的材料以打开大门的最前沿，并为预计的高科技应用程序铺平了绿色经济。