Natural product inspired synthetic methods

天然产物启发的合成方法

• 批准号: 327572-2009
• 负责人: Pagenkopf, Brian
• 金额: $ 4.37万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=481783
• 关键词: Natural; product; inspired; synthetic; methods

The proposed research program involves three primary areas of investigation. One of these features the cobalt catalyzed aerobic oxidations of 5-hydroxy pentenes for THF synthesis, the application of these oxidations in total synthesis, expanding reaction scope and improving catalyst performance. Recent highlights in this area from our lab include the asymmetric total syntheses of the natural products bullatacin and aplysiallene. A major synthetic target described in the proposal is amphidinolide C. A second area of investigation involves the discovery of new reactions of donor-acceptor cyclopropanes and their application in total synthesis. This work has provided new syntheses of pyrroles, indoles, indolizines and other useful heterocycles, and was a key reaction in a recent total synthesis of goniomitine. Ongoing investigations will look for additional annelation partners and cyclopropane motifs, as well as targets for total synthesis. A third major area of research involves collaborative work on silole based materials. Our group performs the syntheses and further studies, particularly electrogenerated chemiluminesence and photo voltaic responses, are measured in the Ding and Semenikhin groups.

拟议的研究计划涉及调查的三个主要领域。这些特征之一是钴催化5-羟基五戊烯的有氧有氧氧化，用于THF合成，这些氧化在总合成中的应用，扩大反应范围并改善催化剂性能。 我们实验室的最新亮点包括天然产物的不对称总合成和丙烯酸酯。该提案中描述的主要合成靶标是Amphidinolide C.第二个研究区域涉及发现供体 - 受体环丙烷的新反应及其在完全合成中的应用。 这项工作为吡咯，吲哚，吲哚和其他有用的杂环提供了新的合成，并且是近期陀螺素的总合成中的关键反应。正在进行的研究将寻找其他网状伴侣和环丙烷基序，以及总合成的靶标。研究的第三个主要领域涉及基于硅洛的材料的协作工作。 我们的小组在丁基和塞内金基团中测量了合成和进一步的研究，尤其是电生成的化学函数和照片伏响应。