Electrochemical biosensors for point-of-care diagnostics

用于即时诊断的电化学生物传感器

• 批准号: RGPIN-2020-05884
• 负责人: Merle, Geraldine
• 金额: $ 2.4万
• 依托单位: École Polytechnique de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=740892
• 关键词: Electrochemical; biosensors; point; care; diagnostics

Current technologies for in vitro and clinical assessment are costly, complicated, labour intensive, and time-consuming. Additionally, since molecular diagnostic tests and instrumentation are complex, they require highly knowledgeable and expert scientists to establish benchmarks. And so, they cannot provide real time decision support. The important unmet need (the primary driver behind my research program) is to develop easy-to-use, quick, and affordable electrochemical analytical solutions that can be easily implemented in either a clinical environment or the remote areas.  Recent literature has indicated that overexpression of metalloproteins - proteins which contain metal atoms or clusters have been associated with human health and diseases. Based on the overall hypothesis that some diseases overexpress specific metalloproteins, and that their metals can interact directly with an electrode surface and specifically display reversible electrochemistry, I aim to electrochemically detect those biomarkers with innovative sensing devices to assist clinicians in taking decisions. As an expert in the synthesis of functional nanomaterials, and electroconductive substrate, here, over the next 5 years, my research objectives will be to focus on 1) designing and building a multifunctional platform of advanced conductive materials and functional interface for the electrochemical detection and monitoring of metalloproteins and pathogens for health and environmental analysis and management, 2) modifying traditional electrochemical cells into tools adapted to in vivo environment, and 3) evaluating these innovative implantable electrochemical devices to aid in disease detection and management, and monitoring healing.  My research program provides excellent training environment for HQP due to it interdisciplinary nature involving materials science, biomedical engineering, electrochemistry. The training is further enriched by the benefit of testing our electrochemical devices in vivo and in clinical environment with real end-product users.  This research program will develop medicaltech platforms technology will not only be important for both academia and industry. Further, they aim to reduce the economic burden to health care services by providing more accurate and more immediate analyses of disease and normal physiology.

当前的体外技术和临床评估是昂贵的，劳动量的，劳动的诊断测试和仪器很复杂在临床环境或远程区域中可以轻松实施的植物化学分析溶液表明，过度去蛋白质 - 蛋白质 - 蛋白质 - 基于假设的金属蛋白可以与人类的蛋白质相关An。 -ON 1）设计和建造高级导电材料和功能，以用于电化学和金属蛋白进行健康，环境分析和管理的锻炼，2）将传统的电化学物质修改为适合于体内环境的OLS，3）评估创新的植入式化学化学物质以帮助帮助疾病的检测和管理，监测AM，因为它跨学科的自然材料科学提供了出色的训练环境，这进一步培训了，从而在体内和临床环境中与真实的最终产品进行了测试。 CH平台技术将对EMIA和ES进行，通过提供更准确，更直接的疾病和正常生理学分析。