Sensor driven serodiagnostics for infection and immunity in COVID-19

传感器驱动的 COVID-19 感染和免疫血清诊断

• 批准号: 555032-2020
• 负责人: Merle, Geraldine
• 金额: $ 3.64万
• 依托单位: École Polytechnique de Montréal
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=705788
• 关键词: Sensor; driven; serodiagnostics; infection; immunity

This Alliance COVID-19 project will develop a new made-in-Canada sensor for COVID-19 and is easily translatable to the next pandemic viral threat. This academic and industrial alliance aim to deliver point-of-care serodiagnostic testing with a rapid turnaround to protect both patients and health care personnel. In addition to the industry partners, NXTSens and MY01 Inc- which will provide technical support for sensor design and regulatory as well as use of their manufacturing pipeline (MY01. io)), a corporate partner in Sherbrooke, QC (Immune Biosolutions Inc- will supply the team with COVID Spike protein and consultation on use. This research project fulfills all objectives of the NSERC's mandate by accelerating the availability of high-quality and real-time evidence to support Canada's rapid response to the global pandemic in order to better detect, treat and/or manage COVID-19. Here we aim to develop a field-effect transistor (FET)-based biosensing device for detecting SARS-CoV-2 through the spike protein. Our system will be able to detect and determine specifically the proportion if any of IgM and IgG Abs in test droplets and assess simultaneously whether patient is infected or immunized. This proposal will enable Canadian engagement and coordination in national and international large-scale trials and/or better enable harmonized data collection, sharing of data, and rapid large-scale evaluation of impact. It will provide evidence to inform clinical and health system management and public health response, and decision-making and planning within and across jurisdictions in Canada and internationally.

该联盟 COVID-19 项目将为 COVID-19 开发一种新的加拿大制造传感器，并且可以轻松转化为下一个大流行病毒威胁。该学术和工业联盟旨在提供快速周转的护理点血清诊断检测，以保护患者和医护人员。除了行业合作伙伴 NXTSens 和 MY01 Inc（将为传感器设计和监管以及其制造流程 (MY01.io) 的使用提供技术支持）之外，位于 QC 舍布鲁克的企业合作伙伴 (Immune Biosolutions Inc- 将为团队提供 COVID Spike 蛋白并提供使用咨询 该研究项目通过加速提供高质量和实时证据来支持加拿大对新冠病毒的快速反应，从而实现了 NSERC 任务的所有目标。为了更好地检测、治疗和/或管理 COVID-19，我们的目标是开发一种基于场效应晶体管 (FET) 的生物传感设备，通过刺突蛋白检测 SARS-CoV-2。能够具体检测和确定测试液滴中 IgM 和 IgG 抗体的比例，并同时评估患者是否被感染或免疫。该提案将使加拿大能够参与和协调国家和国际大规模试验和/或更好地实现协调一致。数据收集、共享数据，并快速大规模评估影响。它将提供证据，为加拿大和国际司法管辖区内部和跨司法管辖区的临床和卫生系统管理、公共卫生应对以及决策和规划提供信息。