Electrochemical biosensors for point-of-care diagnostics

用于即时诊断的电化学生物传感器

• 批准号: RGPIN-2020-05884
• 负责人: Merle, Geraldine
• 金额: $ 2.4万
• 依托单位: École Polytechnique de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=718059
• 关键词: Electrochemical; biosensors; point; care; diagnostics

Current technologies for in vitro and clinical assessment are costly, complicated, labour intensive, and time-consuming. Additionally, since molecular diagnostic tests and instrumentation are complex, they require highly knowledgeable and expert scientists to establish benchmarks. And so, they cannot provide real time decision support. The important unmet need (the primary driver behind my research program) is to develop easy-to-use, quick, and affordable electrochemical analytical solutions that can be easily implemented in either a clinical environment or the remote areas. Recent literature has indicated that overexpression of metalloproteins proteins which contain metal atoms or clusters have been associated with human health and diseases. Based on the overall hypothesis that some diseases overexpress specific metalloproteins, and that their metals can interact directly with an electrode surface and specifically display reversible electrochemistry, I aim to electrochemically detect those biomarkers with innovative sensing devices to assist clinicians in taking decisions. As an expert in the synthesis of functional nanomaterials, and electroconductive substrate, here, over the next 5 years, my research objectives will be to focus on 1) designing and building a multifunctional platform of advanced conductive materials and functional interface for the electrochemical detection and monitoring of metalloproteins and pathogens for health and environmental analysis and management, 2) modifying traditional electrochemical cells into tools adapted to in vivo environment, and 3) evaluating these innovative implantable electrochemical devices to aid in disease detection and management, and monitoring healing. My research program provides excellent training environment for HQP due to it interdisciplinary nature involving materials science, biomedical engineering, electrochemistry. The training is further enriched by the benefit of testing our electrochemical devices in vivo and in clinical environment with real end-product users. This research program will develop medicaltech platforms technology will not only be important for both academia and industry. Further, they aim to reduce the economic burden to health care services by providing more accurate and more immediate analyses of disease and normal physiology.

目前的体外和临床评估技术成本高昂、复杂、劳动力密集且耗时。此外，由于分子诊断测试和仪器很复杂，因此需要知识渊博的专家科学家来建立基准。因此，他们无法提供实时决策支持。重要的未满足需求（我的研究计划背后的主要驱动力）是开发易于使用、快速且经济实惠的电化学分析解决方案，这些解决方案可以在临床环境或偏远地区轻松实施。 最近的文献表明，含有金属原子或金属簇的金属蛋白的过度表达与人类健康和疾病有关。基于一些疾病过度表达特定金属蛋白，并且它们的金属可以直接与电极表面相互作用并特异性地表现出可逆电化学的总体假设，我的目标是利用创新的传感设备以电化学方式检测这些生物标志物，以协助临床医生做出决策。 作为功​​能纳米材料和导电基底合成方面的专家，在未来5年里，我的研究目标将集中在1）设计和构建先进导电材料和功能界面的多功能平台，用于电化学检测和监测金属蛋白和病原体以进行健康和环境分析和管理，2）将传统电化学电池改造为适应体内环境的工具，3）评估这些创新的可植入电化学装置以帮助疾病检测和管理以及监测愈合。 我的研究项目由于涉及材料科学、生物医学工程、电化学等跨学科性质，为HQP提供了良好的培训环境。通过与真正的最终产品用户一起在体内和临床环境中测试我们的电化学设备，培训进一步丰富。 该研究计划将开发医疗技术平台技术不仅对学术界和工业界都很重要。此外，他们的目标是通过提供更准确、更即时的疾病和正常生理学分析来减轻医疗保健服务的经济负担。