Development of Functional Materials for Battling Bacterial Contamination

对抗细菌污染的功能材料的开发

• 批准号: RGPIN-2019-06094
• 负责人: Liu, Song
• 金额: $ 2.4万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=715925
• 关键词: Development; Functional; Materials; Battling; Bacterial

Bacterial contamination can facilitate corrosion of hard-to-maintain/repair underground pipelines, and cause foodborne illnesses and hospital acquired infections. Materials play a pivotal role in warding off the detrimental bacterial contamination. My established research program focuses on developing innovative antibacterial materials and coatings, and understanding the contact-kill mode of action of those materials and coatings. In view of the negative impact of discharged biocides to the environment and the increasing threat of antibiotic resistance, it is desirable to develop biocidal coatings that do not release extra biocides into the environment and can be repeatedly reactivated to be biocidal by the already routinely used biocides, and develop antibacterial materials that can potentially serve as alternatives for antibiotics and do not induce bacterial resistance. N-chloramines refer to a group of compounds with an N-Cl single bond, in which Cl bears a partial positive charge and is oxidative. After killing bacteria, N-chloramines are converted to their precursor amines/amides which can be turned into N-chloramines again by chlorine bleach. Importantly, no bacterial resistance is reported against N-chloramines. However, many fundamental questions remain about the N-chloramine technology. The current proposal describes a research program that invents new N-chloramine-based antibacterial materials and investigates their interactions with corrosion-inducing and pathogenic bacteria, laying a solid foundation for the development of a new generation of functional biocidal materials with great utility in industrial and healthcare sectors. We will develop new N-chloramine-based antibacterial coatings that resist proteins and can be regenerated by very dilute chlorine (1-90ppm), and N-chloramine-based selective biocidal nanoparticles that are unlikely to induce bacterial resistance. This proposed research program is anticipated to lay a solid foundation for the successful development of 1) innovative rechargeable antibacterial coatings that can be applied to various surfaces to minimize bacteria caused corrosion, bacterial transmission in the environment and in food processing processes, and 2) bacteria selective biocidal nanoparticles as antibiotic alternatives. Our results will be of significant interest to the antibacterial materials community, as it will represent a new perspective of tackling bacterial contamination and elucidate the contact-kill mechanism. This research program will continue to position my research group as an international leader in the area of antibacterial functional materials. The research will provide opportunities for 2 PhD, 2 MSc and 5 BSc students to receive comprehensive training in technical skills that are in high demand by potential employers in material engineering and biomedical engineering sectors. My interdisciplinary training environment will attract new partnerships with local and international industry.

细菌污染会促进难以维护/维修的地下管道的腐蚀，并导致食源性疾病和医院获得性感染。材料在防止有害细菌污染方面发挥着关键作用。我制定的研究计划侧重于开发创新的抗菌材料和涂层，并了解这些材料和涂层的接触杀灭作用模式。鉴于排放的杀菌剂对环境的负面影响以及抗生素耐药性日益严重的威胁，需要开发不会向环境中释放额外杀菌剂并且可以通过已经常规使用的杀菌剂反复重新活化以发挥杀菌作用的杀菌涂料。 ，并开发可以作为抗生素替代品并且不会诱导细菌耐药性的抗菌材料。 N-氯胺是指一组具有N-Cl单键的化合物，其中Cl带有部分正电荷，具有氧化性。杀死细菌后，N-氯胺转化为其前体胺/酰胺，后者可以通过氯漂白剂再次转化为 N-氯胺。重要的是，没有报道细菌对 N-氯胺产生耐药性。然而，N-氯胺技术仍然存在许多基本问题。目前的提案描述了一项研究计划，该项目发明了新型N-氯胺基抗菌材料，并研究了它们与腐蚀诱导细菌和致病细菌的相互作用，为开发在工业和工业领域具有巨大用途的新一代功能性杀菌材料奠定了坚实的基础。医疗保健行业。我们将开发新型基于 N-氯胺的抗菌涂层，可以抵抗蛋白质，并且可以通过非常稀的氯（1-90ppm）再生，以及基于 N-氯胺的选择性杀菌纳米颗粒，不太可能引起细菌耐药性。这项拟议的研究计划预计将为以下方面的成功开发奠定坚实的基础：1) 创新的可充电抗菌涂层，可应用于各种表面，以最大限度地减少细菌引起的腐蚀、环境和食品加工过程中的细菌传播，以及 2) 细菌选择性杀菌纳米颗粒作为抗生素替代品。我们的结果将引起抗菌材料界的重大兴趣，因为它将代表解决细菌污染并阐明接触杀灭机制的新视角。该研究计划将继续使我的研究小组成为抗菌功能材料领域的国际领导者。该研究将为 2 名博士生、2 名硕士生和 5 名理学士生提供接受材料工程和生物医学工程领域潜在雇主急需的技术技能全面培训的机会。我的跨学科培训环境将吸引与本地和国际行业的新合作伙伴关系。