Rechargeable potent antiviral facemasks with a novel quaternized N-chloramine (Lab2Market)

含有新型季铵化 N-氯胺的可充电强效抗病毒口罩 (Lab2Market)

基本信息

批准号：
571238-2022
负责人：
Liu, Song
金额：
$ 1.46万
依托单位：
University of Manitoba
依托单位国家：
加拿大
项目类别：
Idea to Innovation
财政年份：
2021
资助国家：
加拿大
起止时间：
2021-01-01 至 2022-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=729092
关键词：
Rechargeable potent antiviral facemasks novel

项目摘要

Respirators and face masks such as N-95 respirators and surgical masks have become ubiquitous as a control measure to prevent transmission of SARS-CoV-2. However, the COVID-19 pandemic has highlighted several issues with currently available face masks. Since existing mask designs do not actively kill SARS-CoV-2, there is a risk of contact transmission after touching contaminated PPE. SARS-CoV-2 has been demonstrated to survive on various surfaces: on an N-95 mask the virus persists up to 21 days. Consumption of disposable facemasks also raises environmental concerns due to rapid waste generation. Our proposed solution is a reusable facemask endowed with rechargeable antiviral properties which offers a variety of benefits, including active killing of a SARS-CoV-2, reduced risk of contamination during handling and reduced waste. Our group has developed proprietary N-chloramine based antimicrobials which can be covalently bonded to textiles to endow them with self-disinfecting properties. The N-chloramine structure binds oxidative chlorine, which can transfer to microbes such as SARS-CoV-2 through direct contact to cause rapid death. The antimicrobial activity can be recharged by exposing the textile to dilute household bleach. Our novel N-chloramine technology utilizes two added quaternary ammonium groups in the structure to achieve more efficient binding of oxidative chlorine compared to previous N-chloramine technologies. Furthermore, our textiles are durable to 50 laundering cycles while retaining antiviral activity. This is an improvement over commercially available antiviral facemasks with impregnated antiviral compounds which leach out during washing. We are currently developing a three-layer facemask which incorporates our breakthrough N-chloramine technology to "trap and zap" SARS-CoV-2 in the airstream. Our N-chloramine will be incorporated in both the outer cotton layer of the mask and an electrospun nanofibrous filtration membrane to be inserted into the middle pocket of the mask. The antiviral activity of the mask can be recharged via home laundering with bleach, which creates a reusable, effective and environmentally friendly alternative to the masks available on the market.

作为防止 SARS-CoV-2 传播的控制措施，N-95 呼吸器和外科口罩等呼吸器和口罩已变得无处不在。然而，COVID-19 大流行凸显了目前可用口罩的几个问题。由于现有的口罩设计不能主动杀死 SARS-CoV-2，因此在接触受污染的个人防护装备后存在接触传播的风险。 SARS-CoV-2 已被证明可以在各种表面上存活：在 N-95 口罩上，病毒可存活长达 21 天。由于废物的快速产生，一次性口罩的消耗也引起了环境问题。我们提出的解决方案是一种可重复使用的口罩，具有可充电的抗病毒特性，具有多种优点，包括主动杀死 SARS-CoV-2、降低处理过程中的污染风险和减少浪费。我们的团队开发了专有的 N-氯胺抗菌剂，可以与纺织品共价结合，赋予纺织品自我消毒的特性。 N-氯胺结构结合氧化氯，可通过直接接触转移至SARS-CoV-2等微生物，导致快速死亡。通过将纺织品暴露在稀释的家用漂白剂中可以恢复抗菌活性。与以前的 N-氯胺技术相比，我们的新型 N-氯胺技术利用结构中添加的两个季铵基团来实现更有效的氧化氯结合。此外，我们的纺织品可耐 50 次洗涤，同时保留抗病毒活性。这是对市售抗病毒口罩的改进，该口罩含有浸渍的抗病毒化合物，这些化合物在清洗过程中会滤出。我们目前正在开发一种三层口罩，该口罩采用了我们突破性的 N-氯胺技术，可以“捕获并消灭”气流中的 SARS-CoV-2。我们的 N-氯胺将被纳入口罩的外棉层和静电纺丝纳米纤维过滤膜中，以插入口罩的中间口袋。口罩的抗病毒活性可以通过使用漂白剂进行家庭洗涤来补充，这为市场上的口罩创造了可重复使用、有效且环保的替代品。