FUNDAMENTALS AND APPLICATIONS OF PLASMONICS AND ULTRAFAST LASERS IN THERANOSTIC NANOMEDECINE

等离激元和超快激光在治疗纳米医学中的基础知识和应用

• 批准号: RGPIN-2018-05288
• 负责人: Meunier, Michel
• 金额: $ 2.99万
• 依托单位: École Polytechnique de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=713574
• 关键词: FUNDAMENTALS; APPLICATIONS; PLASMONICS; ULTRAFAST; LASERS

Nanomedicine, the branch of nanotechnology dealing with bringing applications to the medical world, seeks to deliver a valuable set of research biomedical tools and clinically useful devices and approaches, such as nano-optical biosensors and targeted therapy. It is anticipated that nanomedecine will also find its applications in the new developing theranostics approaches, a proposed process involving combined therapy and diagnostic for individual patients. The proposed research program specifically deals with the applications of optics to nanomedecine, mostly emphasising the physics and engineering developments. Two interrelated approaches and tools involving plasmonics and ultrashort pulses will be developed. Bioplasmonics exploits the optical properties of metallic nanostructures at the nanoscale and can be used to either detect very low concentrations of analytes, image specific cells or organs or transmit locally energy for therapeutic purposes. Due to its ultrashort pulses, the use of femtosecond lasers offers new ways to interact with materials, nanomaterials and biological media and opens up innovative approaches to biodetection, imaging, surgery and therapy. The aim of the proposed research program is to develop and model new plasmonic nanostructures and ultrafast laser nanoprocesses for theranostic biomedical applications, such as biosensing, hyperspectral imaging, cell transfection, cancer therapy, eye surgery, gene therapy and neuron stimulation with the long term objective to introduce new devices and approaches for nanomedecine applications, such as imaging, biodetection and therapy. Over the five year period, the Discovery research program will contribute to the training of 10 undergraduate students, 4 masters, 5 PhDs, 2 Postdoctoral fellows, and one part time technician. These highly qualify personnels will be trained in nanotechnologies and laser technologies for various applications in nanomedecine which are highly relevant to many Canadian biomedical industries, research centers, universities and hospitals. In summary, this research will bring new basic knowledge, materials and technologies for imaging, biodetection and therapy for the expanding important field of nanomedecine and theranostics. We anticipate that the findings and developed technologies will improve Canadian's quality of life and could potentially save lives.

纳米医学是针对医疗界应用应用的纳米技术分支，旨在提供一套宝贵的研究生物医学工具以及临床上有用的设备和方法，例如纳米光学生物传感器和靶向疗法。可以预计，纳米甲胺还将在新开发的治疗方法中找到其应用，这是一个涉及组合治疗和对个别患者诊断的过程。拟议的研究计划专门讨论了光学对纳米类动物的应用，主要是强调物理和工程的发展。将开发两种相互关联的方法和涉及等离子间脉冲的工具。 Bioplasmonics利用金属纳米结构在纳米级的光学特性，可用于检测非常低浓度的分析物，图像特定细胞或器官或用于治疗目的的局部能量。由于其超短脉冲，使用飞秒激光器的使用提供了与材料，纳米材料和生物学媒体相互作用的新方法，并为生物进行成像，成像，手术和治疗提供了创新的方法。拟议的研究计划的目的是开发和建模新的等离激元纳米结构和超快激光纳米高精油，以进行治疗生物医学应用，例如生物传感，高光谱成像，细胞转染，癌症治疗，癌症治疗，眼睛手术，眼睛手术，基因治疗，基因治疗，基因治疗和神经元的刺激，以引入新的群体和方法，以介绍新的保护和方法，以进行新的保护和方法。 治疗。在五年的时间里，发现研究计划将有助于对10名本科生，4名硕士，5位博士学位，2名博士后研究员和一名兼职技术员进行培训。这些高度合格的人将接受纳米技术和激光技术的培训，用于纳米甲胺的各种应用，这些应用与许多加拿大生物医学行业，研究中心，大学和医院高度相关。总而言之，这项研究将带来新的基础知识，材料和技术，用于成像，生物调整和疗法，以扩大纳米甲甲基和疗法的重要领域。我们预计发现和发展的技术将改善加拿大的生活质量，并有可能挽救生命。