Impact of low dose radiation during late gestation on homeostatic control of metabolism and cellular function

妊娠晚期低剂量辐射对代谢和细胞功能稳态控制的影响

• 批准号: 494077-2016
• 负责人: Tai, TzeChun
• 金额: $ 4.9万
• 依托单位: Laurentian University of Sudbury
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=696586
• 关键词: Impact; low; dose; radiation; during

Living organisms are continually exposed to ionizing radiation. While high-dose exposure to ionizing radiation is known to cause harm, the impact of low-dose exposure remains contentious. Furthermore, the impact of exposure to ionizing radiation during late fetal development is poorly understood. Northern Ontario School of Medicine, Laurentian University, Lakeheahed University, McMaster University and Bruce Power have partnered together to study the fundamental biological effects of fetal exposure to low dose radiation on cellular development and function associated with stress and metabolism. This research will take a targeted approach in examining the physiological risks and/or benefits of low dose radiation exposure during late gestation, and examine the cellular and molecular mechanisms involved. Fundamental research will be performed to examine 3 key areas: 1) Effects of dose and timing of exposure to ionizing radiation during late gestation, 2) Role of reactive oxygen species (ROS) in initiating cellular changes, and 3) Potential adaptive and cellular responses to low dose radiation. The scientific knowledge gained will be beneficial in understanding the impact of environmental and occupational exposure to low dose radiation.

生物体持续暴露于电离辐射。虽然已知高剂量暴露于电离辐射会造成伤害，但低剂量暴露的影响仍然存在争议。 此外，人们对胎儿发育后期暴露于电离辐射的影响知之甚少。 北安大略医学院、劳伦森大学、莱克希德大学、麦克马斯特大学和 Bruce Power 合作研究胎儿暴露于低剂量辐射对细胞发育以及与压力和新陈代谢相关的功能的基本生物影响。 这项研究将采取有针对性的方法来检查妊娠晚期低剂量辐射暴露的生理风险和/或益处，并检查所涉及的细胞和分子机制。 将进行基础研究以检查 3 个关键领域：1) 妊娠晚期电离辐射暴露剂量和时间的影响，2) 活性氧 (ROS) 在引发细胞变化中的作用，以及 3) 潜在的适应性和细胞反应至低剂量辐射。 获得的科学知识将有助于了解环境和职业暴露于低剂量辐射的影响。