Comorbidity: Substance Use Disorders and Other Psychiatric Conditions

合并症：药物使用障碍和其他精神疾病

• 批准号: 8847313
• 负责人: JAMES R. ALLEN
• 金额: $ 26.52万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8847313
• 关键词: Comorbidity; Substance Use Disorder

DESCRIPTION (provided by applicant): Long-term goals: Among the current portfolio of NIDA funded training grants, none have comorbidity as a primary focus. This is striking given co-occurrence prevalence of Substance Use Disorders (SUD) with other psychiatric conditions and health conditions (e.g. diabetes), and the extent to which either SUD or the comorbid disorder can go under- or untreated in conventional treatment settings. Enhancing research expertise to improve diagnostic, treatment and prevention strategies is essential. The proposed program will develop a cadre of scientists with research expertise in comorbidity mechanisms, antecedents and correlates, diagnostics, and psychosocial and pharmacological interventions. Component objectives are to provide each trainee with a working knowledge of comorbidity research including: (a) translational science from Early Phase Clinical Trials to Community Based Participatory Research perspectives; (b) effective research strategies for comorbid conditions across populations and ethnic and cultural groups (e.g. American Indian, Hmong, Somali). Accomplishing programmatic features will capitalize on (a) the spectrum of faculty expertise providing mentoring across multiple areas, and (b) integration across training programs and departments. Key Elements: (1) Involvement of scientists and clinicians with diverse expertise and a core internal advisory group. Primary sites (4 postdoctoral trainees, 2 yrs each) are the Departments of Psychiatry (UMN Twin Cities) and Biobehavioral Health & Population Science (UMN Duluth), supported by the Psychology Department (UMTC) and other UMN entities; (2) Recruitment, including under represented group outreach, of rigorously screened PhD and MD candidates with SUD and comorbidity as primary career focus; (3) Training with an interdisciplinary mentoring team (primary & 2 secondary mentors) with complementary expertise; (4) Formal training plans with clear milestones including trainee development of an NIH application initiated in Year 1; (5) Active research, seminars, didactic course work, workshops, and development of management, ethics, and regulatory expertise; (6) Dynamic program administration entailing monitoring with enhancements and problem resolution along with continued contact with trainees after completion and; (7) Annually convened external advisory group. Resources: Mentor funding sources include NIH Institutes, NSF, Minnesota Medical Foundation, and pharmaceutical industry. Key Personnel and Primary Mentors are directors of clinics, centers, or departments with significant resources. The program focuses on trainee expertise in SUD co-occurring with psychiatric disorders (Anxiety, ADHD, Borderline, Eating, Depression, Schizophrenia, Trauma).

描述（由申请人提供）： 长期目标：在 NIDA 资助的当前培训补助金组合中，没有一个将合并症作为主要关注点。鉴于物质使用障碍 (SUD) 与其他精神疾病和健康状况（例如糖尿病）同时发生的普遍性，以及 SUD 或共病疾病在传统治疗环境中可能治疗不足或未得到治疗的程度，这一点是惊人的。加强研究专业知识以改进诊断、治疗和预防策略至关重要。拟议的计划将培养一支在合并症机制、前因和相关因素、诊断以及心理社会和药物干预方面具有研究专业知识的科学家骨干队伍。组成部分的目标是为每位学员提供共病研究的实用知识，包括： (a) 从早期临床试验到基于社区的参与性研究视角的转化科学； (b) 针对不同人群、种族和文化群体（例如美洲印第安人、苗族、索马里人）共存疾病的有效研究策略。完成计划功能将利用（a）教师专业知识范围，提供跨多个领域的指导，以及（b）跨培训计划和部门的整合。关键要素：(1) 具有不同专业知识的科学家和临床医生以及核心内部咨询小组的参与。主要地点（4名博士后实习生，每人2年）是精神病学系（UMN双城）和生物行为健康与人口科学（UMN德卢斯），由心理学系（UMTC）和其他UMN实体支持； (2) 招募经过严格筛选的博士和医学博士候选人，包括招募代表性不足的群体，并将 SUD 和合并症作为主要职业重点； (3) 接受专业知识互补的跨学科导师团队（初级导师和二级导师）的培训； (4) 具有明确里程碑的正式培训计划，包括第一年启动的 NIH 应用程序的学员开发； (5) 积极的研究、研讨会、教学课程、讲习班以及管理、道德和监管专业知识的发展； (6) 动态计划管理，包括监测、改进和问题解决，以及完成后与学员的持续联系； (7) 每年召开一次外部顾问小组会议。资源：导师资金来源包括 NIH 研究所、NSF、明尼苏达医学基金会和制药行业。关键人员和主要导师是拥有大量资源的诊所、中心或部门的主任。该计划的重点是学员在与精神疾病（焦虑、多动症、边缘性、饮食、抑郁、精神分裂症、创伤）同时发生的 SUD 方面的专业知识。