Biomedical Engineering

生物医学工程

• 批准号: CRC-2017-00338
• 负责人: Willerth, Stephanie
• 金额: $ 7.29万
• 依托单位: University of Victoria
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=695998
• 关键词: Biomedical; Engineering

Dr. Willerths research program develops innovative strategies for engineering personalized neural tissues. Current methods for generating neural tissues require lengthy, low throughput, labor-intensive processes. The major objectives of this program include 1) using novel bioinks to 3D print neural tissues using stem cells and 2) directly engineering neural tissue by reprogramming mature cells into neurons, the main functional cells of the nervous system. 3D bioprinting and direct reprogramming address the limitations of currently used methods. This proposed work will validate these engineered neural tissues as novel tools for drug screening and understanding disease.

Willerth 博士的研究项目开发了工程个性化神经组织的创新策略。目前生成神经组织的方法需要漫长、低通量、劳动密集型的过程。该项目的主要目标包括 1) 使用新型生物墨水利用干细胞 3D 打印神经组织，2) 通过将成熟细胞重新编程为神经元（神经系统的主要功能细胞）来直接改造神经组织。 3D 生物打印和直接重编程解决了当前使用方法的局限性。这项拟议的工作将验证这些工程神经组织作为药物筛选和理解疾病的新工具。