NMR Systems Upgrade for a Sustainable New Era

核磁共振系统升级，迎接可持续发展的新时代

基本信息

批准号：
RTI-2020-00491
负责人：
Tsantrizos, Youla
金额：
$ 10.93万
依托单位：
McGill University
依托单位国家：
加拿大
项目类别：
Research Tools and Instruments
财政年份：
2019
资助国家：
加拿大
起止时间：
2019-01-01 至 2020-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=693797
关键词：
NMR Systems Upgrade Sustainable New

项目摘要

Eight NMR instruments are housed in the Chemistry Department of McGill University and supports the training and research of more than 300 Chemistry HQPs per year in 32 different research groups in that Department. Additionally, there are many other HQPs and PIs from other departments at McGill and other academic institutions within Canada whose research requires the use of these NMR instruments. Therefore, the Helium Recovery Instrument requested by the five co-applicants of this NSERC RTI is submitted on behalf of all the users of the NMR instruments in the Chemistry Department of McGill University. The instrument requested is a necessary upgrade for a sustainable new era in NMR studies, and will allow the optimal use of the PIs' NSERC Discovery Grants for maximum research productivity and HQP training.******Examples of research applications from the five co-applicants include the general use of NMR for characterization of small molecules, characterization of biomolecular interactions with small ligands and mechanistic studies for understanding catalytic transformations. Arndtsen's research focuses on the development of new transition metal catalyzed reactions, which range from metal catalyzed, bond-forming chemistry, multicomponent coupling reactions, to C-H bond functionalizations. As such, his HQPs rely exclusively upon the use of NMR analysis for monitoring reactions and catalyst development. Gleason's research focuses on novel organocatalysts for a range of synthetic transformations, such as polyene cyclizations, oxy-Cope and cycloaddition chemistry. His studies include exploring the fundamental underlying mechanisms, which requires careful kinetic analysis, including 13C isotope experiments, that make extensive use of high-field NMR. Li's research focuses on unconventional and novel chemical transformations that can change the efficiency of chemical synthesis into more Green and Sustainable Chemistry. Each one of his research projects involves extensive liquid and solid-state NMR characterization of compounds and use of NMR for mechanistic studiers. Tsantrizos' research aims to exploit the molecular recognition elements affecting enzymatic and chemically-mediated catalytic processes. Her group is designing phosphorus-containing molecules that can be used as enzyme inhibitors and as ligands in metal-mediated and organocatalytic asymmetric synthesis. In the course of these investigations, NMR studies are required to elucidate the enzyme-bound conformation of ligands and catalyst-substrate interactions. Trempe's investigations focus on elucidating protein-protein interactions involving PINK1 and Parkin, two proteins that work together in a mitochondrial quality control pathway implicated in Parkinson's disease. His investigations require extensive NMR HSQC titration experiments using 15N- and 13C- labeled proteins and high-field spectrometers. **

麦吉尔大学化学系有八种NMR仪器，并支持该部门32个不同研究小组的300多个化学HQP的培训和研究。此外，麦吉尔（McGill）和加拿大其他学术机构的其他部门还有许多其他HQP和PI，其研究需要使用这些NMR工具。因此，该NSERC RTI的五个共同申请者要求的氦恢复工具代表麦吉尔大学化学系的NMR工具的所有用户提交。该仪器要求在NMR研究中进行可持续新时代的必要升级，并将允许最佳使用PIS的NSERC Discovery Grants，以最大程度地研究研究生产力和HQP培训。******五个研究应用程序的示例共同应用包括NMR的一般用途，用于表征小分子，表征与小配体的生物分子相互作用以及用于理解催化转化的机械研究。 Arndtsen的研究集中于新的过渡金属催化反应的发展，范围从金属催化，形成键的化学，多组分耦合反应到C-H键函数化。因此，他的HQP仅依赖于使用NMR分析来监测反应和催化剂的发展。格里森（Gleason）的研究着重于一系列合成转化的新型有机催化剂，例如多烯环化，氧气和环加成化学。他的研究包括探索基本的潜在机制，这些机制需要仔细的动力学分析，包括13C同位素实验，这些实验可以广泛使用高场NMR。 Li的研究集中于非常规和新颖的化学转化，这些化学合成的效率可以将化学合成的效率转化为更绿色和可持续的化学。他的每个研究项目都涉及化合物的广泛液体和固态NMR表征，并将NMR用于机械研究者。 Tsantrizos的研究旨在利用影响酶促和化学介导的催化过程的分子识别元件。她的小组正在设计含磷的分子，可以用作金属介导的和有机催化的不对称合成中的酶抑制剂和配体。在这些研究过程中，需要NMR研究来阐明配体和催化剂 - 基底相互作用的酶结合构象。 Trempe的研究着重于阐明涉及Pink1和Parkin的蛋白质 - 蛋白质相互作用，这两种蛋白质在与帕金森氏病有关的线粒体质量控制途径中一起起作用。他的研究需要使用15N和13C标记的蛋白质和高场光谱仪进行广泛的NMR HSQC滴定实验。 **