Design and synthesis of molecular tools that modulate metabolic pathways- implications for drug discovery

调节代谢途径的分子工具的设计和合成——对药物发现的影响

• 批准号: 121762-2010
• 负责人: Tsantrizos, Youla
• 金额: $ 2.91万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=522201
• 关键词: Design; synthesis; molecular; tools; modulate

Oncogenesis and viral replication require energy and macromolecular precursors that are often derived from the metabolic networks of the host cell. Cancer and viral infections also disrupt the normal production of numerous host proteins that are crucial to cell physiology. My research program aims to provide molecular tools that can be used to explore the biochemical role of metabolic enzymes and other host proteins that are involved in these important disease states. Towards this goal, my group embraces a Chemical Biology approach in addressing key questions that probe the role and interactions between important human proteins, in the context of an intact biological system. These studies can provide valuable innovations at the early stages of new drug discovery programs aiming at developing novel antitumor and antiviral human therapeutics.

肿瘤发生和病毒复制需要能量和大分子前体，这些前体通常源自宿主细胞的代谢网络。 癌症和病毒感染也破坏了对细胞生理至关重要的众多宿主蛋白的正常产生。 我的研究计划旨在提供分子工具，可用于探索代谢酶和其他涉及这些重要疾病状态的宿主蛋白的生化作用。 为了实现这一目标，我小组采用了一种化学生物学方法，可以解决在完整的生物系统中探测重要人类蛋白质之间作用和相互作用的关键问题。 这些研究可以在旨在开发新型抗肿瘤和抗病毒人类疗法的新药物发现计划的早期阶段提供宝贵的创新。