Mechatronic Device for Multimodal Suppression of Parkinsonian Tremor

帕金森震颤多模式抑制机电装置

• 批准号: 523838-2018
• 负责人: Trejos, AnaLuisa
• 金额: $ 10.58万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=693597
• 关键词: Mechatronic; Device; Multimodal; Suppression; Parkinsonian

Tremor, one of the most disabling symptoms of Parkinson's disease (PD), significantly affectsthe lives of patients. Traditional medicines are often ineffective and surgery is highly invasiveand risky. A new approach to managing tremor includes using devices that involve eithermechanical suppression via actuators (e.g., motors that apply forces), or electricalsuppression (using a modulated electrical signal to stimulate the muscles involved ingenerating tremor). Unfortunately, the devices that have been presented in the literature aretoo heavy and cumbersome for daily use by patients and none are currently commerciallyavailable.Building on our previous work, the objective of this project is to develop a device that cansuppress tremor motion by combining both mechanical suppression and electrical stimulation.Compared to other devices that use mechanical suppression alone, this device is expected tobe more compact in size, lower in weight, and offer an extended battery life. Compared todevices that use electrical stimulation alone, this device is expected to be able to suppressmotion better and to decrease pain and discomfort.To conduct this work, we will design smart control systems that adapt to the patients ability totolerate electrical stimulation. We will design new actuators using smart materials. We willinvestigate how to electrically stimulate muscle when combined with mechanical suppression.Finally, a validation experiment will be performed on individuals with PD to determine thefeasibility of the device for clinical use.The expected outcome of this project will be a first prototype of a tremor suppression devicethat effectively incorporates both mechanical suppression and electrical stimulation. This newtechnology will be greatly beneficial to patients who are disabled by tremor of the wrist andfingers and is expected to significantly improve their ability to perform activities of daily living.

震颤是帕金森氏病（PD）最残疾的症状之一，对患者的生活产生了重大影响。传统药物通常无效，手术高度侵入式风险。一种管理震颤的新方法包括使用涉及通过执行器（例如，施加力的电动机）或电抑制的设备（使用调制电信号来刺激涉及摄入震动的肌肉）。 Unfortunately, the devices that have been presented in the literature aretoo heavy and cumbersome for daily use by patients and none are currently commerciallyavailable.Building on our previous work, the objective of this project is to develop a device that cansuppress tremor motion by combining both mechanical suppression and electrical stimulation.Compared to other devices that use mechanical suppression alone, this device is expected tobe more compact in size, lower in weight, and offer an extended battery 生活。相比之下，仅使用电刺激的招待部门，该设备有望能够更好地抑制和减轻疼痛和不适感。为了进行这项工作，我们将设计适合患者能力促进电刺激的智能控制系统。我们将使用智能材料设计新的执行器。我们将在与机械抑制结合使用时将对如何进行电刺激的肌肉。在本文中，将对具有PD的个体进行验证实验，以确定该设备的临床用途的可行性。该项目的预期结果将是tremor抑制的第一个原型，有效地融合了机械抑制和电刺激。这种新技术将对因手腕和fing弱的震颤而残疾的患者非常有益，并有望显着提高其进行日常生活活动的能力。