Translational Multimodal Strategy for Peri-Implant Disease Prevention

种植体周围疾病预防的转化多模式策略

• 批准号: 10736860
• 负责人: Geelsu Hwang
• 金额: $ 52.13万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10736860
• 关键词: 3-Dimensional; Address; Adhesions; Adhesives; Affect; Age; Alveolar Bone Loss; Anti-Bacterial Agents; Anti-Inflammatory Agents; Apoptosis; Bacterial Adhesion; Bicuspid; Biomechanics; Bite Force; Bone Resorption; Cell Communication; Cell Proliferation; Cell Survival; Cell physiology; Cells; Clinical; Coculture Techniques; Crowns; Data; Dental General Practice; Dental Implants; Dental Plaque; Dental crowns; Development; Disease; Dose; Engineering; Environment; Epithelial Cells; Failure; Fibroblasts; Future; Generations; Gingiva; Goals; Head; Human; Implant; In Situ; Individual; Inflammation; Inflammation Mediators; Inflammatory; Inflammatory Response; Invaded; Joint Prosthesis; Ligature; Light; Limb Prosthesis; Longevity; Mastication; Measures; Mechanics; Mediating; Microbe; Microbial Biofilms; Modeling; Molar tooth; Motion; Mucositis; Operative Surgical Procedures; Oral; Osseointegration; Outcome; Pathogenesis; Patients; Periodontitis; Phenotype; Phototherapy; Populations at Risk; Production; Property; Protocols documentation; Recording of previous events; Resistance; Risk Reduction; Rupture; Sampling; Secure; Self Assessment; Signal Pathway; Silk; Smoking; Stimulus; Structure; Surface; System; Systemic disease; Testing; Tissues; Titanium; Tooth structure; Toothbrushing; United States; X-Ray Computed Tomography; alveolar bone; antimicrobial; antimicrobial peptide; clinical examination; clinical practice; cytokine; disorder prevention; dosage; efficacy evaluation; efficacy testing; electrical potential; experimental study; healing; human tissue; implantable device; in vivo Model; in vivo evaluation; innovation; keratinocyte; light emission; microCT; microbial; multimodality; next generation; novel; oral pathogen; particle; pathogenic microbe; peri-implantitis; photobiomodulation; porcine model; preservation; prevent; response; restoration; seal; self assembly; senescence; soft tissue; tissue culture

Dental implants have become an important routine component of dental practice with over five million fixtures placed annually in the United States and this number is expected to increase significantly in the future. The peri-implant soft tissue interface is less effective than natural teeth in resisting bacterial invasion, enhancing vulnerability to subsequent peri-implant disease. Peri-implant diseases are inflammatory conditions affecting the soft/hard tissues surrounding a functional dental implant. Plenty of experimental evidence indicates that the accumulation of dental plaque at the soft tissue-implant interface and the subsequent local inflammatory response seems to be key in the pathogenesis of peri-implant mucositis. Furthermore, in certain individuals, it will progress to peri-implantitis, resulting in alveolar bone loss and implant failure. The goal of this application is to create a novel dental implant construct that renders the implant-supported restoration antibiofilm while providing a tight gingival tissue-implant seal that serves as a barrier to bacterial invasion. This smart dental implant system is a battery-less system that converts biomechanical forces from human oral motions (e.g., chewing or tooth-brushing) into electrical energy and powers light-emitting diodes that enable in situ phototherapy. When used in combination with a long-lasting antibiofilm restorative surface, this self-powered precision phototherapy system circumvents problems with the use of conventional antimicrobials. Ongoing studies indicate that red and near-infrared light is effective in maintaining human gingival tissue cell viability in the face of mono- and multi-microbial challenges. Furthermore, the antibiofilm restorative surface almost completely inhibits bacterial colonization. Based on these exciting supporting data, we hypothesize that force- powering of piezoelectric crystals to produce red and near-infrared light combined with bacterial anti-adhesive restorations creates an anti-inflammatory, pro-healing environment that provides a robust soft-tissue seal and prevents the development of peri-implantitis. We anticipate that the creation of this next-generation anti- inflammatory, antibiofilm dental implant system would increase functionality and provide a new strategy to prevent and control peri-implant diseases, especially in populations at risk, and reduce the risk of implant failure.

牙科植入物已成为牙科实践的重要常规组成部分，超过500万个固定装置 每年放置在美国，预计将来这个数字将大大增加。这 种植体植入软组织界面在抵抗细菌侵袭方面的有效性较小，增强 随后的植入植物疾病的脆弱性。种植体疾病是影响的炎症状况 功能性牙齿植入物周围的软/硬组织。大量实验证据表明 在软组织植入物界面和随后的局部炎症处积累牙菌斑 反应似乎是种植体周围粘膜炎的发病机理的关键。此外，在某些人中 将发展为植入植入术，导致肺泡骨质流失和植入物衰竭。该应用的目的是 创建一种新型的牙科植入物构建体，该结构可提供植入物支持的修复抗体胶片。 提供紧密的牙龈组织 - 植入植物密封，可作为细菌侵袭的障碍。这个聪明的牙科 植入物系统是一种无电池系统，可转换人类口服运动的生物力学力（例如， 咀嚼或牙刷）进入电能，并为启用原位的发光二极管供电 光疗。当与持久的抗生素恢复表面结合使用时，这种自动驱动 精度光疗系统规定了使用常规抗菌剂的问题。正在进行 研究表明，红色和近红外光有效地维持人牙龈组织细胞的活力 单一和多微型挑战的面孔。此外，几乎 完全抑制细菌定植。基于这些令人兴奋的支持数据，我们假设该力量 压电晶体的动力产生红色和近红外光与细菌抗粘合剂结合 修复体创造了一种抗炎，亲修的环境，可提供强大的软组织密封和 防止植入体炎的发展。我们预计将创建这一下一代反 - 炎症性，抗生素牙科植入物系统将提高功能，并为 预防和控制种植体疾病，尤其是在处于危险中的人群中，并降低植入风险 失败。