Bio-microelectromechanical Systems (BioMEMS)

生物微机电系统（BioMEMS）

• 批准号: 1000231505-2017
• 负责人: SanatiNezhad, Amir
• 金额: $ 8.74万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=693089
• 关键词: Bio; microelectromechanical; Systems; BioMEMS

The development of biomimetic human tissue models is central to biomedical engineering and drug discovery for screening the toxicity of chemicals and therapeutics. This research involves the multidisciplinary engineering of the skin and liver tissues using sensor-integrated multiorgan-on-chip platforms. This interdisciplinary work is novel due to the combination of sophisticated biomedical engineering techniques for the development of skin and liver tissues, integrated sensors, as well as characterizing the crosstalk of interconnected skin and liver in response to drugs. Completion of this work will contribute to the understanding of toxicity of cosmetics and dermal drugs on the skin and liver tissues.

仿生人体组织模型的开发对于生物医学工程和筛选化学品和治疗药物毒性的药物发现至关重要。这项研究涉及使用传感器集成的多器官芯片平台对皮肤和肝脏组织进行多学科工程。这项跨学科工作是新颖的，因为它结合了用于开发皮肤和肝脏组织的复杂生物医学工程技术、集成传感器，以及表征相互连接的皮肤和肝脏对药物反应的串扰。这项工作的完成将有助于了解化妆品和皮肤药物对皮肤和肝脏组织的毒性。