Measurement of streaming potential for determination of capillary surface characteristics

测量流动电位以确定毛细管表面特性

• 批准号: 531138-2018
• 负责人: Chen, David
• 金额: $ 1.82万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=647320
• 关键词: Measurement; streaming; potential; determination; capillary

The proposed project aims to use a new capillary electrophoresis instrument manufactured in the local area to**characterize the surface properties of capillaries coated with various coating materials. Capillary**electrophoresis has become one of the most important analytical separation techniques used in the analysis of**biopharmaceutical industry, biomedical research, and industrial manufacturing activities. Reproducibility of**chemical analysis is essential for all analytical methods. Maintaining a chemically clean surface for the**capillary used in CE in one of the critical conditions for obtaining reproducible migration times. The applicant**will develop strategies and methods to evaluate the relationship between the streaming potential with different**capillary surface conditions, different buffer systems, and different covalent and non-covalent surface coatings.**The results will provide important guidance for researchers and other instrument users in their method**development to generate high quality and reproducible results.

拟议的项目旨在使用在当地生产的新毛细管电泳仪器，以**表征涂有各种涂层材料的毛细管的表面特性。毛细管**电泳已成为用于分析**生物制药行业，生物医学研究和工业制造活动中最重要的分析分离技术之一。 **化学分析的可重复性对于所有分析方法至关重要。在获得可重复的迁移时间的关键条件之一中，在CE中使用的**毛细管保持化学干净的表面。申请人**将制定策略和方法，以评估不同**毛细血管表面条件，不同缓冲液系统以及不同共价和非共价表面涂层之间的流势之间的关系。**结果将为研究人员和其他仪器用户提供重要的指导。