Controlled microfluidic flow synthesis of brightly luminescent semiconducting polymer dot nanoparticles for bioanalysis********

用于生物分析的明亮发光半导体聚合物点纳米颗粒的受控微流体流动合成********

• 批准号: 537692-2018
• 负责人: Algar, Russ
• 金额: $ 1.68万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=643735
• 关键词: Controlled; microfluidic; flow; synthesis; brightly

Nanoparticles, which are particles that exist on a size scale a thousand times smaller than the width of a human hair, have tremendous potential for diagnostic and therapeutic medicine, as well as fundamental health science research. For many nanoparticle materials, a major roadblock is controllable and reproducible manufacturing. We will partner with Precision Nanosystems Inc. (PNI) to develop a microfluidic method for the synthesis of semiconducting polymer dots (Pdots)--a type of extraordinarily bright fluorescent nanoparticle that has prospective applications in biological detection, imaging, and combined therapy and diagnosis (so-called "theranostics"). It is anticipated that the proposed microfluidic synthesis method will provided greatly enhanced control, reproducibility, and scalability versus current laboratory methods of Pdot synthesis. These improvements will accelerate the translation of Pdot materials from R&D to practical applications (e.g. clinical).

纳米颗粒的尺寸比人毛的宽度高1000倍，具有巨大的诊断和治疗医学潜力，以及基本的健康科学研究。对于许多纳米颗粒材料，主要的障碍是可控且可再现的制造。我们将与Precision Nanosystems Inc.（PNI）合作，开发一种微流体方法，用于合成半导体聚合物点（PDOTS） - 一种具有前瞻性荧光纳米颗粒，该纳米颗粒具有前瞻性应用于生物检测，成像和诊断，以及联合疗法以及联合疗法，以及联合诊断，以及联合诊断，以及联合诊断，以及联合诊断，以及联合诊断和诊断（所谓的“ Theranostics”）。预计提出的微流体合成方法将极大地增强控制，可重复性和可伸缩性与当前PDOT合成实验室方法。这些改进将加速PDOT材料从研发到实际应用（例如临床）的翻译。