Role of cortisol in the physiological response to toxicants in fish

皮质醇在鱼类对毒物的生理反应中的作用

• 批准号: RGPIN-2015-04161
• 负责人: Hontela, Alice
• 金额: $ 2.4万
• 依托单位: University of Lethbridge
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630793
• 关键词: Role; cortisol; physiological; response; toxicants

The physiological stress response is elicited when organisms are exposed to potentially harmful stimuli. Cortisol is a key hormonal effector of the response at tissue level in fish. The stress response has been characterized for many species and diverse stressors, including toxicants, yet key fundamental questions remain: is the stress response beneficial or detrimental to the organism during exposure to toxicants; is vulnerability to toxicants related to robustness of the response? The goal of the proposed research is to elucidate the role of cortisol in the physiological response to toxicants in fish and test the hypothesis that cortisol has beneficial effects under acute potentially lethal toxicant exposures, but is detrimental, engendering significant metabolic costs, under sublethal chronic exposures.

当生物体暴露于潜在有害刺激时，就会引发生理应激反应。皮质醇是鱼类组织水平反应的关键激素效应物。许多物种和不同压力源（包括毒物）的应激反应已被表征，但关键的基本问题仍然存在：在暴露于毒物期间，应激反应对生物体是有益还是有害？对毒物的脆弱性与反应的稳健性有关吗？拟议研究的目的是阐明皮质醇在鱼类对毒物的生理反应中的作用，并检验以下假设：皮质醇在急性潜在致命毒物暴露下具有有益作用，但在亚致死慢性暴露下是有害的，会产生显着的代谢成本。