Maternal hair cortisol concentrations, prenatal psychopathology and offspring behavioral phenotypes

母亲头发皮质醇浓度、产前精神病理学和后代行为表型

• 批准号: 10642855
• 负责人: Bizu Gelaye
• 金额: $ 18.57万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10642855
• 关键词: Acute; Adrenal Glands; Affect; Anxiety; Behavior assessment; Behavioral; Biological; Biological Assay; Biological Markers; Biological Process; Brain; Calendar; Cardiometabolic Disease; Cardiovascular Diseases; Child; Child Health; Complex; Conceptions; Data; Data Set; Development; Equity; Fetal Development; Funding; Goals; Hair; Health; Hispanic; Hydrocortisone; Intervention; Knowledge; Link; Longevity; Longitudinal Studies; Longitudinal cohort; Low income; Maternal Health; Maternal and Child Health; Measurement; Measures; Mediation; Mental Depression; Mental Health; Mental disorders; Methodology; Methods; Mission; Mothers; National Institute of Mental Health; Outcome; Participant; Perinatal; Peru; Phenotype; Physiological; Plasma; Population; Post-Traumatic Stress Disorders; Postpartum Period; Pregnancy; Psychopathology; Public Health; Reproducibility; Research; Research Design; Resources; Risk; Risk Factors; Role; Saliva; Salivary; Sampling; Serum; Strategic Planning; Stress; System; Testing; Time; Trauma; United States National Institutes of Health; Urine; Variant; Woman; Work; analytical method; behavioral health; behavioral outcome; behavioral phenotyping; biological adaptation to stress; burden of illness; clinically significant; cohort; cost effective; early pregnancy; experience; fetal; high risk population; hypothalamic-pituitary-adrenal axis; innovation; insight; intergenerational; neurodevelopment; novel; offspring; perinatal health; phenotypic data; post pregnancy; pregnancy health; prenatal; prenatal exposure; prospective; psychologic; research study; response; sound; steroid hormone; stressor

PROJECT SUMMARY / ABSTRACT Background: The hypothalamic–pituitary–adrenal (HPA) axis is one of the body’s natural stress-response systems and is critically involved in multiple biological processes. When triggered by stressors, the HPA axis stimulates the secretion of cortisol throughout the body. In the past, characterization of cortisol was limited by the use of acute cortisol concentration indicators (saliva, urine, plasma). More recently, measurement of cortisol in hair has emerged as a cost-effective means of assaying integrated HPA axis activity. This study seeks to characterize hair cortisol concentration (HCC) and evaluate which factors affect cortisol concentration in a large and well-characterized cohort from Lima, Peru (N=2,700). Another primary study aim is to evaluate the effects of HPA axis dysregulation in relation to maternal experiences of trauma and perinatal psychopathology. We will estimate the extent to which HPA axis dysregulation is associated with offspring behavioral outcomes. Finally, we aim to evaluate the extent to which HCC acts as a driver of the association between maternal psychopathology and offspring health outcomes. Implications: The proposed research is innovative in three major ways. First, we leverage one of the few cohorts with prospectively collected hair samples among a high-risk population. Second, we use a novel method of assessing long-term cortisol secretion in hair that opens the door for a new era of biologically sound studies on the role of stress in a myriad of health outcomes including perinatal health outcomes. Third, we use advanced analysis including mediation analytic methods to assess the causal effects of HPA axis dysregulation in offspring behavioral health risk. This application is consistent with the NIMH Strategic Plan Strategy 2.2: “Identify and understand risk factors, biomarkers, and behavioral indicators of mental illness and of intervention response across the lifespan.” This project will provide foundational knowledge about cortisol, a central molecule in mental health research and will inform our understanding of risk factors that affect child neurodevelopment.

项目概要/摘要 背景：下丘脑-垂体-肾上腺（HPA）轴是人体自然的压力反应之一 当压力源触发时，HPA 轴会参与多种生物过程。 刺激全身皮质醇的分泌 过去，皮质醇的表征受到以下因素的限制。 最近，使用急性皮质醇浓度指标（唾液、尿液、血浆）进行测量。 头发中的皮质醇已成为测定综合 HPA 轴活性的一种经济有效的方法。 旨在表征头发皮质醇浓度 (HCC) 并评估哪些因素影响皮质醇浓度 来自秘鲁利马的一个大型且特征明确的队列（N = 2,700）的另一个主要研究目的是评估。 HPA 轴失调对母亲创伤和围产期经历的影响 我们将估计 HPA 轴失调与后代的相关程度。 最后，我们的目的是评估 HCC 在多大程度上作为该关联的驱动因素。 母亲精神病理学与后代健康结果之间的关系。 意义：拟议的研究是。 首先，我们利用了少数几个前瞻性收集头发的群体之一。 其次，我们使用一种评估长期皮质醇的新方法。 头发中的分泌物为从生物学角度研究压力在众多疾病中的作用的新时代打开了大门 第三，我们使用包括调解在内的高级分析。 评估 HPA 轴失调对后代行为健康风险的因果影响的分析方法。 该应用程序符合 NIMH 战略计划 2.2：“识别并了解风险因素， 精神疾病和整个生命周期干预反应的生物标志物和行为指标。” 项目将提供有关皮质醇的基础知识，皮质醇是心理健康研究的核心分子，并将 帮助我们了解影响儿童神经发育的风险因素。