Developmental Mechanisms of Neurogenesis

神经发生的发育机制

• 批准号: RGPIN-2016-03737
• 负责人: Burke, Robert
• 金额: $ 3.21万
• 依托单位: University of Victoria
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629326
• 关键词: Developmental; Mechanisms; Neurogenesis

Most of what we know about the embryonic development of nervous systems comes from studies of flies or mice. As those studies revealed similar signaling systems and molecular pathways, it was proposed that nervous systems arose once, early in the history of multicellular animals. Subsequent studies in several types of invertebrates support this idea, but the striking diversity in how nervous systems develop makes it difficult to rationalize a single origin. A more refined explanation is that there has been independent evolution of the cellular organization in many groups and neurogenesis has drawn upon conserved signaling systems and molecular pathways in various ways as animals diversified. We lack the models necessary to test this hypothesis, as the molecular and cellular mechanisms underlying neurogenesis need to be carefully analyzed to make useful comparisons in groups of related animals.

我们对神经系统的胚胎发育的了解中的大多数来自对苍蝇或小鼠的研究。正如这些研究揭示了相似的信号系统和分子途径的那样，有人提出，在多细胞动物史的早期，神经系统曾经出现一次。随后对几种无脊椎动物的研究支持了这一想法，但是神经系统发展方式的惊人多样性使得很难合理化单个起源。一个更精致的解释是，在许多群体中，细胞组织已经独立演变，随着动物的多样化，神经发生以各种方式吸引了保守的信号传导系统和分子途径。我们缺乏检验该假设所需的模型，因为需要仔细分析神经发生的分子和细胞机制，以便在相关动物组中进行有用的比较。